Behavioral tagging underlies memory reconsolidation

Rabinovich Orlandi, Iván; Fullio, Camila L.; Schroeder, Matías Nicolás; Giurfa, Martin; Ballarini, Fabricio; Moncada, Diego

Artículo de Publicación Periódica:
Behavioral tagging underlies memory reconsolidation

dc.contributor.author	Rabinovich Orlandi, Iván
dc.contributor.author	Fullio, Camila L.
dc.contributor.author	Schroeder, Matías Nicolás
dc.contributor.author	Giurfa, Martin
dc.contributor.author	Ballarini, Fabricio
dc.contributor.author	Moncada, Diego
dc.date	info:eu-repo/date/embargoEnd/2020-02-01
dc.date.accessioned	2020-10-28T15:50:27Z
dc.date.available	2020-10-28T15:50:27Z
dc.date.issued	2020-07
dc.description.abstract	"Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate that a memory retrieving event sets a neural tag, which enables the reconsolidation of memory after binding proteins provided by the original or a different contiguous experience. We characterized the specific temporal window during which this association is effective and identified the protein kinase A (PKA) and the extracellular signalregulated kinase 1 and 2 (ERK 1/2) pathways as the mechanisms related to the setting of the reconsolidation tag and the synthesis of proteins. Our results show, therefore, that memory reconsolidation is mediated by a “behavioral tagging” process, which is common to different memory forms. They represent a significant advance in understanding the fate of memories reconsolidated while being adjacent to other events, and provide a tool for designing noninvasive strategies to attenuate (pathological/traumatic) or improve (education-related) memories. "	en
dc.identifier.issn	0027-8424
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/3217
dc.language.iso	en	en
dc.relation	info:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2009517117
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2015-2320/AR. Ciudad Autónoma de Buenos Aires
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	CONSOLIDACION DE LA MEMORIA	es
dc.subject	ETIQUETADO CONDUCTUAL	es
dc.title	Behavioral tagging underlies memory reconsolidation	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Rabinovich Orlandi, Iván. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiation	Fil: Rabinovich Orlandi, Iván. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
itba.description.filiation	Fil: Fullio, Camila L. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiation	Fil: Fullio, Camila L. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
itba.description.filiation	Fil: Schroeder, Matías Nicolás. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiation	Fil: Giurfa, Martin. Université de Toulouse
itba.description.filiation	Fil: Giurfa, Martin. Fujian Agriculture and Forestry University; China
itba.description.filiation	Fil: Ballarini, Fabricio. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiation	Fil: Ballarini, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
itba.description.filiation	Fil: Ballarini, Fabricio. Instituto Tecnológico de Buenos Aires; Argentina