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dc.contributor.authorD'hers, Sebastián
dc.contributor.authorAbad Vázquez, Agustín
dc.contributor.authorGurman, Pablo
dc.contributor.authorElman, Noel M.
dc.date.accessioned2020-01-06T18:42:03Z
dc.date.available2020-01-06T18:42:03Z
dc.date.issued2019-06
dc.identifier.issn2190-393X
dc.identifier.urihttp://ri.itba.edu.ar/handle/123456789/1856
dc.description.abstract"Current emergency injectors of glucagon require manual reconstitution, which involves several steps that may lead to dosage errors. Rapid reconstitution packages (RRPs) are new devices, designed using computational fluid dynamics (CFD) to optimize fluid mixing, integrating physical properties of active pharmaceutical ingredients (APIs), excipients and diluents. RRPs improve drug stability for long-term storage and ease of delivery. Device prototypes were manufactured using advanced stereolithography apparatus (SLA) 3D printing technology. Reconstitution of glucagon with RRPs was evaluated by highperformance liquid chromatography (HPLC) and optical spectroscopy methods. Enzyme-linked immunosorbent assays were performed to test in vitro activity. Experimental results showed that RRPs effectively reconstituted glucagon even after exposure to 60 °C for a 24-h period. RRPs exhibited improved performance at maintaining drug stability compared to lyophilized glucagon stored in a standard glass vial under the same temperature conditions. RRPs represent a portable platform for rapid reconstitution of lyophilized drugs, compatible with standard syringes available in any clinical setting. The RRP provides an alternative to manual reconstitution process, especially designed for medical emergencies."en
dc.language.isoenes
dc.relationinfo:eu-repo/grantAgreement/GearJump Technologies/US.
dc.relationinfo:eu-repo/grantAgreement/Massachusetts Institute of Technology/W911NF-07-D-0004/US. Massachusetts
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s13346-019-00615-4
dc.subjectLIBERACION CONTROLADA DE DROGASes
dc.subjectACELERADORES MAGNETICOSes
dc.subjectGLUCANONes
dc.subjectDIABETESes
dc.subjectDINAMICA DE FLUIDOSes
dc.titleRapid reconstitution packages (RRPs) for stable storage and delivery of glucagones
dc.typeArtículos de Publicaciones Periódicases
dc.typeinfo:eu-repo/semantics/publishedVersion
itba.description.filiationFil: D'hers, Sebastián. Instituto Tecnológico de Buenos Aires; Argentina.es
itba.description.filiationFil: Abad Vázquez, Agustín. GearJump Technologies; Estados Unidos.es
itba.description.filiationFil: Gurman, Pablo. GearJump Technologies; Estados Unidos.es
itba.description.filiationFil: Elman, Noel M. GearJump Technologies; Estados Unidos.es


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