Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon

D'hers, Sebastián; Abad Vázquez, Agustín; Gurman, Pablo; Elman, Noel M.

Artículo de Publicación Periódica:
Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon

dc.contributor.author	D'hers, Sebastián
dc.contributor.author	Abad Vázquez, Agustín
dc.contributor.author	Gurman, Pablo
dc.contributor.author	Elman, Noel M.
dc.date.accessioned	2020-01-06T18:42:03Z
dc.date.available	2020-01-06T18:42:03Z
dc.date.issued	2019-06
dc.description.abstract	"Current emergency injectors of glucagon require manual reconstitution, which involves several steps that may lead to dosage errors. Rapid reconstitution packages (RRPs) are new devices, designed using computational fluid dynamics (CFD) to optimize fluid mixing, integrating physical properties of active pharmaceutical ingredients (APIs), excipients and diluents. RRPs improve drug stability for long-term storage and ease of delivery. Device prototypes were manufactured using advanced stereolithography apparatus (SLA) 3D printing technology. Reconstitution of glucagon with RRPs was evaluated by highperformance liquid chromatography (HPLC) and optical spectroscopy methods. Enzyme-linked immunosorbent assays were performed to test in vitro activity. Experimental results showed that RRPs effectively reconstituted glucagon even after exposure to 60 °C for a 24-h period. RRPs exhibited improved performance at maintaining drug stability compared to lyophilized glucagon stored in a standard glass vial under the same temperature conditions. RRPs represent a portable platform for rapid reconstitution of lyophilized drugs, compatible with standard syringes available in any clinical setting. The RRP provides an alternative to manual reconstitution process, especially designed for medical emergencies."	en
dc.identifier.issn	2190-393X
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/1856
dc.language.iso	en	en
dc.relation	info:eu-repo/grantAgreement/GearJump Technologies/US.
dc.relation	info:eu-repo/grantAgreement/MIT/W911NF-07-D-0004/US. Massachusetts
dc.relation	info:eu-repo/semantics/altIdentifier/doi/10.1007/s13346-019-00615-4
dc.subject	LIBERACION CONTROLADA	es
dc.subject	ACELERADORES MAGNETICOS	es
dc.subject	GLUCANON	es
dc.subject	DIABETES	es
dc.subject	DINAMICA DE FLUIDOS	es
dc.title	Rapid reconstitution packages (RRPs) for stable storage and delivery of glucagon	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: D'hers, Sebastián. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Abad Vázquez, Agustín. GearJump Technologies; Estados Unidos.
itba.description.filiation	Fil: Gurman, Pablo. GearJump Technologies; Estados Unidos.
itba.description.filiation	Fil: Elman, Noel M. GearJump Technologies; Estados Unidos.