Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever

Barradas, José Sebastián; Errea, María Inés; D´Accorso, Norma B.; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz

Artículo de Publicación Periódica:
Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever

dc.contributor.author	Barradas, José Sebastián
dc.contributor.author	Errea, María Inés
dc.contributor.author	D´Accorso, Norma B.
dc.contributor.author	Sepúlveda, Claudia Soledad
dc.contributor.author	Damonte, Elsa Beatriz
dc.date.accessioned	2022-11-25T15:25:33Z
dc.date.available	2022-11-25T15:25:33Z
dc.date.issued	2011-01
dc.description.abstract	"Herein, we describe the syntheses of 3,5-disubstituted imidazo[2,1-b]thiazole. The cyclization step was performed in two different conditions by using either thermal or microwave heating. Comparing the results of both methodologies, we found that the microwave assistance is an improved alternative to obtain this family of heterocyclic compound. Compounds were first evaluated for cytotoxicity in Vero cells by MTT method and then, the antiviral activity was assayed by a virus yield inhibition assay in the range of concentrations lower than the corresponding CC50, using JUNV strain IV4454 as the model system. The most active compounds (3 and 4), showed a level of antiviral activity against JUNV in monkey Vero cells better than the reference substance ribavirin. Then, they are promising lead compound for further analysis and characterization to establish their therapeutic potential against hemorrhagic fever viruses."	en
dc.identifier.issn	0223-5234
dc.identifier.uri	https://ri.itba.edu.ar/handle/123456789/4038
dc.language.iso	en	en
dc.relation	info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2010.11.012
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	CARBOHIDRATOS	es
dc.subject	RADIACION	es
dc.subject	MICROONDAS	es
dc.subject	VIRUS	es
dc.title	Imidazo[2,1-b]thiazole carbohydrate derivatives: synthesis and antiviral activity against Junin virus, agent of Argentine hemorrhagic fever	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Barradas, José Sebastián. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
itba.description.filiation	Fil: Barradas, José Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Errea, María Inés. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
itba.description.filiation	Fil: Errea, María Inés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Errea, María Inés. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: D´Accorso, Norma B. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
itba.description.filiation	Fil: D´Accorso, Norma B. Universidad de Buenos Aires. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Sepúlveda, Claudia Soledad. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
itba.description.filiation	Fil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.