artículo de publicación periódica.page.titleprefix A combined experimental-computational approach for spatial protection efficacy assessment of controlled release devices against mosquitoes (Anopheles)
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Date
2018-03
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Abstract
"This work describes the use of entomological studies combined with in silico models (computer
simulations derived from numerical models) to assess the efficacy of a novel device
for controlled release of spatial repellents. Controlled Release Devices (CRDs) were tested
with different concentrations of metofluthrin and tested against An. quadrimaculatus mosquitoes
using arm-in cage, semi-field, and outdoor studies. Arm-in-cage trials showed an
approximate mean values for mosquito knockdown of 40% and mosquito bite reduction of
80% for the optimal metofluthrin formulation for a 15-minute trial. Semi-field outdoor studies
showed a mean mortality of a 50% for 24 hour trial and 75% for a 48 hour trial for optimal
concentrations. Outdoors studies showed an approximate mean mortality rate of 50% for a
24 hour trial for optimal concentrations. Numerical simulations based on Computational
Fluid Dynamics (CFD) were performed in order to obtain spatial concentration profiles for 24
hour and 48 hour periods. Experimental results were correlated with simulation results in
order to obtain a functional model that linked mosquito mortality with the estimated spatial
concentration for a given period of time. Such correlation provides a powerful insight in predicting
the effectiveness of the CRDs as a vector-control tool. While CRDs represent an
alternative to current spatial repellent delivery methods, such as coils, candles, electric
repellents, and passive emanators based on impregnated strips, the presented method can
be applied to any spatial vector control treatment by correlating entomological endpoints,
i.e. mortality, with in-silico simulations to predict overall efficacy. The presented work therefore
presents a new methodology for improving design, development and deployment of
vector-control tools to reduce transmission of vector-borne diseases, including malaria and
dengue."
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Keywords
MOSQUITOS, MALARIA, LIBERACION CONTROLADA, REPELENTES, DENGUE, DINAMICA DE FLUIDOS, CONTROL DE VECTORES