artículo de publicación periódica.page.titleprefix
Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling

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dc.contributor.authorBusatto, Carlos
dc.contributor.authorBerkenwald, Emilio
dc.contributor.authorNicolás, Mariano
dc.contributor.authorCasis, Natalia
dc.contributor.authorLuna, Julio
dc.contributor.authorEstenoz, Diana
dc.dateinfo:eu-repo/date/embargoEnd/2018-03-01
dc.date.accessioned2022-04-18T20:25:54Z
dc.date.available2022-04-18T20:25:54Z
dc.date.issued2015-12
dc.description.abstract"The homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) (PLGA) microspheres was investigated. A mathematical model was developed that estimates the evolutions of ester bonds concentrations and average molecular weights along the degradation process. The model is based on a detailed kinetic mechanism that includes the hydrolysis of the different types of ester bonds by random chain scission and considers the effect of polymer chemical composition and molecular structure. Novel and published experimental data were used to adjust and validate the model. The experimental work consisted of homogeneous hydrolytic degradation of PLGA microspheres. The predictions are in very good agreement with the experimental results."en
dc.identifier.issn0141-3910
dc.identifier.urihttp://ri.itba.edu.ar/handle/123456789/3792
dc.language.isoenen
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.polymdegradstab.2015.12.018
dc.relationinfo:eu-repo/grantAgreement/CONICET/PIP/848/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/ANPCyT/PICT/2011-1254/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/UNL/UNLCyT/2011-419/AR. Santa Fe. Santa Fe
dc.subjectESTERESes
dc.titleHomogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modelingen
dc.typeArtículos de Publicaciones Periódicases
dc.typeinfo:eu-repo/semantics/acceptedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: Busatto, Carlos. Universidad Nacional del Litoral; Argentina.
itba.description.filiationFil: Busatto, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Berkenwald, Emilio. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Nicolás, Mariano. Universidad Nacional del Litoral; Argentina.
itba.description.filiationFil: Nicolás, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Casis, Natalia. Universidad Nacional del Litoral; Argentina.
itba.description.filiationFil: Casis, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Luna, Julio. Universidad Nacional del Litoral; Argentina.
itba.description.filiationFil: Luna, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.

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