Detection of progesterone in aqueous samples by molecularly imprinted photonic polymers

Qasim, Sally; Hsu, Shu-Yu; Rossi, Ezequiel; Lin, Chung-Ho; Polo Parada, Luis; Fidalgo de Cortalezzi, María Marta; Salahshoor, Zahra

artículo de publicación periódica.page.titleprefix
Detection of progesterone in aqueous samples by molecularly imprinted photonic polymers

dc.contributor.author	Qasim, Sally
dc.contributor.author	Hsu, Shu-Yu
dc.contributor.author	Rossi, Ezequiel
dc.contributor.author	Lin, Chung-Ho
dc.contributor.author	Polo Parada, Luis
dc.contributor.author	Fidalgo de Cortalezzi, María Marta
dc.contributor.author	Salahshoor, Zahra
dc.date	info:eu-repo/date/embargoEnd/2023-04-02
dc.date.accessioned	2022-11-16T13:17:13Z
dc.date.available	2022-11-16T13:17:13Z
dc.date.issued	2022-04
dc.description.abstract	"A label-free molecular imprinted polymer (MIP) sensor was fabricated for the detection of progesterone in aqueous solutions, by polymerization inside the void spaces of colloidal crystals, which gave them photonic properties. The prepolymerization mixture was prepared from acrylic acid as the functional monomer, ethylene glycol as the cross-linker agent, ethanol as solvent, and progesterone as the imprinted template. After polymerization, the colloidal crystal was removed by acid etching and the target eluted with a solvent. Material characterization included as follows: attenuated total reflectance-Fourier-transform infrared spectroscopy, dynamic light scattering, swelling experiments, and environmental scanning electron microscopy. MIPs were investigated by equilibrium binding, kinetics experiments, and UV–visible spectra to investigate Bragg diffraction peak shift that occurs with the rebinding at different progesterone concentrations in deionized water and 150-mM NaCl solutions. The MIP response was investigated with progesterone concentration in the 1–100 μg L−1 range, with LOD of 0.5 μg L−1, reaching the detected range of hormone in natural waters. Furthermore, hydrogel MIP films were successfully tested in various real water matrices with satisfactory results. Moreover, the MIP film exhibited good selectivity toward the progesterone hormone evidenced by a larger response than when exposed to structurally similar molecules. Computational studies suggested that size along with surface potential influenced the binding of analog compounds. Due to their ease of use and low cost, the sensors are promising as screening tools for the presence of progesterone in aqueous samples."	en
dc.identifier.issn	1436-5073
dc.identifier.uri	https://ri.itba.edu.ar/handle/123456789/4009
dc.language.iso	en	en
dc.relation	info:eu-repo/semantics/altIdentifier/doi/10.1007/s00604-022-05290-w
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	POLIMEROS	es
dc.subject	PROGESTERONA	es
dc.title	Detection of progesterone in aqueous samples by molecularly imprinted photonic polymers	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Qasim, Sally. University of Missouri--Columbia; Estados Unidos.
itba.description.filiation	Fil: Hsu, Shu-Yu. University of Missouri--Columbia; Estados Unidos.
itba.description.filiation	Fil: Rossi, Ezequiel. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Rossi, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Salahshoor, Zahra. University of Missouri--Columbia; Estados Unidos.
itba.description.filiation	Fil: Lin, Chung-Ho. University of Missouri--Columbia; Estados Unidos.
itba.description.filiation	Fil: Polo Parada, Luis. University of Missouri--Columbia; Estados Unidos.
itba.description.filiation	Fil: Fidalgo de Cortalezzi, María Marta. University of Missouri--Columbia; Estados Unidos.