Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach

Colmegna, Patricio; Bianchi, Fernando D.; Sánchez-Peña, Ricardo

artículo de publicación periódica.page.titleprefix
Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach

dc.contributor.author	Colmegna, Patricio
dc.contributor.author	Bianchi, Fernando D.
dc.contributor.author	Sánchez-Peña, Ricardo
dc.date	info:eu-repo/date/embargoEnd/2023-03-17
dc.date.accessioned	2021-01-22T13:49:34Z
dc.date.available	2021-01-22T13:49:34Z
dc.date.issued	2021
dc.description.abstract	"Keeping the blood glucose levels within the safe range during meals and exercise still represents a major hurdle not only for patients with type 1 diabetes (T1D), but also for Artificial Pancreas (AP) systems. One of the reasons a fully (autonomous) closed-loop solution has not been released onto the market yet is the slow action of current insulin analogs. To partially overcome this limitation, the authors have previously designed a switched control strategy equipped with an insulin-on-board (IOB) safety loop that mitigates meal-related glucose excursions without carbohydrate counting. In this paper, a similar strategy based on a Linear Parameter-Varying (LPV) control law has been adapted to safely handle also exercise challenges with minimum user intervention. In silico results using the UVA/Padova simulator evidence that the proposed closedloop scheme is feasible under moderate-intense exercise bouts by effectively and safely reducing the risk of hypoglycemia."	en
dc.identifier.issn	2475-1456
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/3312
dc.language.iso	en	en
dc.relation	info:eu-repo/semantics/reference/10.1109/LCSYS.2020.3041211
dc.relation	info:eu-repo/grantAgreement/Fundación Cellex/ES. Barcelona
dc.relation	info:eu-repo/grantAgreement/Fundación Nuria/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/JDRF/APF/2-APF-2019-373-A-N/US. Nueva York, NY
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	DIABETES	en
dc.subject	PANCREAS	en
dc.subject	ORGANOS ARTIFICIALES	en
dc.subject	CONTROL DE VARIACION LINEAL DE PARAMETROS	en
dc.subject	INSULINA	en
dc.subject	GLUCOSA	en
dc.title	Automatic glucose control during meals and exercise in type 1 diabetes: proof-of-concept in silico tests using a switched LPV approach	en
dc.type	Artículos de Publicaciones Periódicas	en
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Colmegna, Patricio. University of Virginia; Estados Unidos.
itba.description.filiation	Fil: Colmegna, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Bianchi, Fernando D. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Bianchi, Fernando D. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Sánchez-Peña, Ricardo. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Sánchez-Peña, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.