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Browsing Ingeniería by Subject "DIABETES"
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tesis de doctorado.listelement.badge Control-oriented models with intra-patient variations for artificial pancreas systems(2019) Moscoso-Vásquez, Marcela; Sánchez-Peña, Ricardo; Colmegna, Patricio"En los últimos años se ha incrementado el número de investigaciones orientadas al desarrollo de un Páncreas Articial (AP) para la regulación automática de glucosa en pacientes con Diabetes Mellitus Tipo 1 (T1DM). Sin embargo, el riesgo de hiper- e hipoglucemia sigue siendo un impedimento para una regulación adecuada de la glucemia en algunos casos. Una fuente importante de limitaciones se origina a partir de la incertidumbre del modelo, y la alta variabilidad inter- e intra-paciente que afecta la dinámica de la regulación de la glucosa. Por lo tanto, considerando que se requieren herramientas para el diseño de estrategias de control robustas y variables en el tiempo que permitan considerar estos aspectos, esta tesis se centra en desarrollar modelos que permitan integrarlos en la etapa de diseño del controlador."tesis de doctorado.listelement.badge Simulation & control in type 1 diabetes(2015) Colmegna, Patricio; Sánchez-Peña, Ricardo"The study of Type 1 Diabetes has grown exponentially over the years. Thus, a huge number of scientic articles that are focused on this disease can be found. In this thesis, two issues are mainly addressed. Firstly, the most relevant mathematical models that describe the insulin-glucose dynamics are analysed. Through that analysis, the main features of these models are presented, and their advantages and disadvantages are described. Also, several inconsistencies that appear in previous works are pointed out. On the other hand, different control algorithms that are aimed towards maintaining the glucose levels in a safe region are studied. The main challenge is to obtain a controller that achieves safe blood glucose control, despite issues like actuator saturation, measurement noise and high inter- and intra-subject variability. Due to the fact that an articial pancreas scheme involves glucose measurement and insulin infusion through the subcutaneous route, there are delays that make the control problem even more challenging. In addition, in order to minimise the patient self-management of his/her disease, it is assumed that meals are unannounced, i.e., the controller does not receive any warning related to meal times or meal sizes either."