tesis de doctorado.page.titleprefix Control-oriented models with intra-patient variations for artificial pancreas systems
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Date
2019
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Abstract
"En los últimos años se ha incrementado el número de investigaciones orientadas al desarrollo de un Páncreas Articial (AP) para la regulación automática de glucosa en pacientes con Diabetes Mellitus Tipo 1 (T1DM). Sin embargo, el riesgo de hiper- e hipoglucemia sigue siendo un impedimento para una regulación adecuada de la glucemia en algunos casos. Una fuente importante de limitaciones se origina a partir de la incertidumbre del modelo, y la alta variabilidad inter- e intra-paciente que afecta la dinámica de la regulación de la glucosa. Por lo tanto, considerando que se requieren herramientas para el diseño de estrategias de control robustas y variables en el tiempo que permitan considerar estos aspectos, esta tesis se centra en desarrollar modelos que permitan integrarlos en la etapa de diseño del controlador."
"Research on the development of a closed-loop articial pancreas for automatically regulating the blood glucose level in Type 1 Diabetes Mellitus (T1DM) patients has intensied in the past years. However, the risk of hyper- and hypoglycemia remains an impediment to adequate glycemic control in some cases. A signicant source of limitations originates from model uncertainty, and the extremely high inter- and intra-patient variability that affects the dynamics of glucose regulation. Therefore, considering that tools are required for the design of robust and time-varying control strategies that consider these issues, this thesis focuses on developing control-oriented models that allow considering them in the controller design stage."
"Research on the development of a closed-loop articial pancreas for automatically regulating the blood glucose level in Type 1 Diabetes Mellitus (T1DM) patients has intensied in the past years. However, the risk of hyper- and hypoglycemia remains an impediment to adequate glycemic control in some cases. A signicant source of limitations originates from model uncertainty, and the extremely high inter- and intra-patient variability that affects the dynamics of glucose regulation. Therefore, considering that tools are required for the design of robust and time-varying control strategies that consider these issues, this thesis focuses on developing control-oriented models that allow considering them in the controller design stage."
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ORGANOS ARTIFICIALES, PANCREAS, DIABETES, INSULINA, CONTROL ROBUSTO, GLUCOSA