Control Automático

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Real time stable identification: A Nehari/SOS approach
(2007) García Galiñanes, Rafael; Sánchez-Peña, Ricardo; Mancilla-Aguilar, J. L.
"Here we present an adaptive identification algorithm based on Second Order section (SOS) model structures. The procedure guarantees stable transfer functions whenever the actual physical plant is stable, due to an optimal Nehari approximation step performed analytically. The procedure is suitable to be implemented in real time applications. Some examples illustrate the proposed algorithm."
LPV control of glucose for diabetes type I
(2010) Sánchez-Peña, Ricardo; Ghersin, Alejandro S.
"This paper considers the problem of automatically controlling the glucose level in a Diabetes type I patient. Three issues have been considered: model uncertainty, timevarying/nonlinear phenomena and controller implementation. To that end, the dynamical model of the insulin/glucose relation is framed as a Linear Parameter Varying system and a controller is designed based on it. In addition, this framework allows not only a better performance than other classical methods, but also provides stability and performance guarantees. Design computations are based on convex Linear Matrix Inequality (LMI) optimization. Implementation is based on a low order controller whose dynamics adapts according to the glucose levels measured in real-time."
Online guidance updates using neural networks
(2010) Filici, Cristian; Sánchez-Peña, Ricardo
"The aim of this article is to present a method for the online guidance update for a launcher ascent trajectory that is based on the utilization of a neural network approximator. Generation of training patterns and selection of the input and output spaces of the neural network are presented, and implementation issues are discussed. The method is illustrated by a 2-dimensional launcher simulation."
Active noise hybrid time-varying control for motorcycle helmets
(2010-05) Castañé-Selga, Rosa; Sánchez-Peña, Ricardo
"Recent noise at work regulations in the EU (2003) have been established to prevent noise induced hearing loss (NIHL). This imposes better performance results to traditional feedback active noise control (ANC) in motorcycle helmets, which suffer from well known limitations. Here two new ideas are applied to this problem. First, an hybrid (feedforward/feedback) linear time invariant (LTI) controller is designed for a motorcycle helmet ANC, which improves the resulting attenuation. This is achieved by adding an extra pair of microphones which measure the external noise that is then used as the feedforward input signal. In addition and to increase even more the resulting performance, the air velocity is measured in real-time and used as the parameter which schedules a linear parameter varying (LPV) feedback (FB) controller. This is combined with the previous feedforward (FF) controller, resulting in a time-varying hybrid controller. Both hybrid, LTI and LPV controllers are designed using linear matrix inequality (LMI)-based optimization. Two experiments have been carried out to measure the relation between external noise spectra and velocity: a wind tunnel test and a freeway ride experience. The resulting controllers are tested in a simulation which uses actual data obtained from the freeway experiment. The resulting attenuations in this motivating study seem promising for future controller tests to be performed in real-time, with the adequate hardware."
Applied LPV Control with Full Block Multipliers and Regional Pole Placement
(2010-05) Sánchez-Peña, Ricardo; Ghersin, Alejandro S.
"A formulation of an LPV control problem with regional pole placement constraints is presented, which is suitable for the application of a Full Block S-Procedure. It is demonstrated that improved bounds can be obtained on the induced 𝐿2 norm of closed loop systems, while satisfying pole placement constraints. An application consisting in the 6 degrees of freedom (DOF) control of a space vehicle is developed as an example, with hardware in the loop (HIL) simulation. This shows that the method is appealing from the practical point of view, considering that the synthesized control law can be implemented satisfactorily in standard flight control systems. Conclusions with remarks towards the practical use of the method are presented as well."
LPV control of a magnetic bearing experiment
(2010-10) Ghersin, Alejandro S.; Smith, R. S.; Sánchez-Peña, Ricardo
"An LPV (Linear Parameter Varying) controller design example for a Magnetic Bearing System is presented. A linear model of the system including bending modes and imbalance is described. Simulations and experimental results show the usefulness of the LPV method with eigenvalue clustering constraints in spite of the limited rotation rate range. The results show that this method facilitates simulation and allows implementation. Conclusions are drawn on the limited range for the rotation rate the LPV controller allows for."
Time-varying procedures for insulin-dependent diabetes mellitus control
(2011-03) Sánchez-Peña, Ricardo; Ghersin, Alejandro S.; Bianchi, Fernando D.
"This work considers the problem of automatically controlling the glucose level in insulin dependent diabetes mellitus (IDDM) patients. The objective is to include several important and practical issues in the design: model uncertainty, time variations, nonlinearities, measurement noise, actuator delay and saturation, and real time implementation. These are fundamental issues to be solved in a device implementing this control. Two time-varying control procedures have been proposed which take into consideration all of them: linear parameter varying (LPV) and unfalsiﬁed control (UC). The controllers are implemented with low-order dynamics that adapt continuously according to the glucose levels measured in real time in one case (LPV) and by controller switching based on the actual performance in the other case (UC). Both controllers have performed adequately under all these practical restrictions, and a discussion on pros and cons of each method is presented at the end."
Reducing glucose variability due to meals and postprandial exercise in TI DM using switched LPV control: in silico studies
(2016) Colmegna, Patricio; Sánchez-Peña, Ricardo; Gondhalekar, Ravi; Dassau, Eyal; Doyle III, Frank J.
"Time-varying dynamics is one of the main issues for achieving safe blood glucose control in type I diabetes mellitus (TI DM) patients. In addition, the typical disturbances considered for controller design are meals, which increase the glucose level, and physical activity (PA), which increases the subject's sensitivity to insulin. In previous works the authors have applied a linear parameter-varying (LPV) control technique to manage unannounced meals."
Control-oriented linear parameter-varying model for glucose control in type 1 diabetes
(2016) Colmegna, Patricio; Sánchez-Peña, Ricardo; Gondhalekar, Ravi
"The contribution of this paper is a controller design oriented model of insulin-glucose dynamics in Type 1 Diabetes Mellitus (T1DM). The novelty of the proposed model is to more effectively include the time-varying nature, and also the inter-patient variability, associated with the glucose control problem. Importantly, this is achieved in a manner that straightforwardly facilitates well-known and standard controller synthesis procedures. In that way, an average Linear Parameter-Varying (LPV) model that captures the dynamics from the insulin delivery input to the subcutaneous-glucose concentration output is constructed based on the Universities of Virginia (UVA)/Padova metabolic simulator. In addition, a system-oriented reinterpretation of the classical ad-hoc 1800 rule is applied to adapt the model’s gain."
Switched LPV glucose control in type 1 diabetes
(2016-06) Colmegna, Patricio; Sánchez-Peña, Ricardo; Gondhalekar, Ravi; Dassau, Eyal; Doyle III, Frank J.
"The purpose of this work is to regulate the blood glucose level in Type 1 Diabetes Mellitus (T1DM) patients with a practical and flexible procedure that can switch amongst a finite number of distinct controllers, depending on the user´s choice."
Application of robust control to a cryogenic current comparator
(2016-07) Bierzychudek, Marcos E.; Götz, Martin; Sánchez-Peña, Ricardo; Tonina, Alejandra; Iuzzolino, Ricardo; Drung, Dietmar
"We describe the design and implementation of an H ∞ controller for PTB's 14-bit cryogenic current comparator (CCC). Measurement results obtained using either the newly implemented digital H ∞ controller or the conventional analog integrator are consistent. In a wide frequency range, the system's noise figure is improved when using the new controller."
Distributed formation control of multiple unmanned aerial vehicles over time-varying graphs using population games
(2016-12) Barreiro-Gomez, Julian; Mas, Ignacio; Ocampo-Martínez, Carlos; Sánchez-Peña, Ricardo; Quijano, Nicanor
"This paper presents a control technique based on distributed population dynamics under time-varying communication graphs for a multi-agent system structured in a leader-follower fashion. Here, the leader agent follows a particular trajectory and the follower agents should track it in a certain organized formation manner. The tracking of the leader can be performed in the position coordinates x, y, and z, and in the yaw angle φ. Additional features are performed with this method: each agent has only partial knowledge of the position of other agents and not necessarily all agents should communicate to the leader. Moreover, it is possible to integrate a new agent into the formation (or for an agent to leave the formation task) in a dynamical manner. In addition, the formation configuration can be changed along the time, and the distributed population-games-based controller achieves the new organization goal accommodating conveniently the information-sharing graph in function of the communication range capabilities of each UAV. Finally, several simulations are presented to illustrate different scenarios, e.g., formation with time-varying communication network, and time-varying formation."
Application of robust control to a cryogenic current comparator
(2017-06) Bierzychudek, Marcos E.; Götz, Martin; Sánchez-Peña, Ricardo; Iuzzolino, Ricardo; Drung, Dietmar
"This paper describes the implementation of a digital robust controller in a cryogenic current comparator. The controller was designed applying H∞ control theory and it was programmed in a home-made digital unit. Experimental comparisons of the new robust controller with the conventional analog integrator have showed a significant improvement of stability robustness and noise rejection in the system."
Artificial Pancreas: first clinical trials in Argentina
(2017-07) Sánchez-Peña, Ricardo; Colmegna, Patricio; Grosembacher, Luis; Breton, Marc; De Battista, Hernán; Garelli, Fabricio; Belloso, Waldo H.; Campos-Náñez, Enrique; Simonovich, Ventura; Beruto, Valeria; Scibona, Paula; Cherñavvsky, Daniel
"The first clinical trials using an Artificial Pancreas (AP) in Latin America have been defined in 2 stages. The first stage was carried out in November 2016 with the UVA controller (developed by the Center for Diabetes Technology and already clinically tested), and the second will be performed during the first semester of 2017 with the ARG (Automatic Regulation of Glucose) algorithm (developed by ITBA, UNQ, and UNLP in Argentina). Both tests are based on the DiAs (Diabetes Assistant) from the UVA, and are performed in the HIBA on 5 patients with Type 1 Diabetes Mellitus (T1DM), for 36 hours. For the first stage, Open-Loop (OL) insulin boluses were applied before meals and patient's physical activity was included. On the other hand, for the second stage, patients will not be involved in physical activity, but no OL insulin boluses will be injected before meals. In this work, experimental results from the first stage with the UVA controller, and preliminary results with the ARG control algorithm tested on the UVA/Padova simulator are presented. Due to the final paper deadline, the experimental results from the second stage are not included here, but will be presented at the IFAC World Congress."
Closed-loop in neuroscience: can a brain be controlled?
(2018) García Violini, Demián; Bertone-Cueto, Nicolás I.; Martínez, Sebastián; Chiesa Docampo, Franco; de la Fuente, Verónica; Belluscio, Mariano; Piriz, Joaquín; Sánchez-Peña, Ricardo
"An experimental setup capable of stimulating, inhibiting, sensing, processing and analyzing a iological system is presented. The experimental setup is based on open-source, open hardware commercial devices. It can be applied to record and control neuronal activity, for example to stablish causal links between neurons and behavior in a closed-loop fashion. Cells or group of cells can be triggered by acoustical, electrical or light impulses. This last case is based on a technique defined as optogenetics. The latter is used in an example that reads and controls neuronal activity of a population of neurons in laboratory rats forcing them to transition between neuronal states, illustrates the system developed in this work. Index Terms—Optogenetics, closed-loop, automatic control, open-source, open-hardware."
Linear parameter-varying model to design control laws for an artificial pancreas
(2018-02) Colmegna, Patricio; Sánchez-Peña, Ricardo; Gondhalekar, Ravi
"The contribution of this work is the generation of a control-oriented model for insulin-glucose dynamic regulation in type1 diabetes mellitus (T1DM). The novelty of this model is that it includes the time-varying nature, and the inter-patient variability of the glucose-control problem. In addition, the model is well suited for well-known and standard controller synthesis procedures. The outcome is an average linear parameter-varying (LPV) model that captures the dynamics from the insulin delivery input to the glucose concentration output constructed based on the UVA/Padova metabolic simulator. Finally, a system-oriented reinterpretation of the classical ad-hoc 1800 rule is applied to adapt the model’s gain."
Automatic regulatory control in type 1 diabetes without carbohydrate counting
(2018-05) Colmegna, Patricio; Garelli, Fabricio; De Battista, Hernán; Sánchez-Peña, Ricardo
"A new approach to automatically regulate the glucose level in type 1 diabetes is presented in this work. This is the so-called Automatic Regulation of Glucose (ARG) algorithm, which is based on a switched Linear Quadratic Gaussian (LQG) inner controller, combined with an outer sliding mode safety loop with Insulin on Board (IOB) constraints. In silico and in vivo results without feedforward insulin boluses delivered at meal times indicate that safe blood glucose control can be achieved by the proposed controller. This controller is simple to migrate to well-known hardware platforms, and intuitive to tune using a priori clinical information."
Data-driven fault diagnosis and robust control: application to PEM fuel cell systems
(2018-08) Ocampo-Martínez, Carlos; Sánchez-Peña, Ricardo; Bianchi, Fernando D.; Ingimundarson, Ari
"A data-driven methodology that includes the unfalsified control concept in the framework of fault diagnosis and isolation (FDI) and fault-tolerant control (FTC) is presented. The selection of the appropriate controller from a bank of controllers in a switching supervisory control setting is performed by using an adequate FDI outcome. By combining simultaneous online performance assessment of multiple controllers with the fault diagnosis decision from structured hypothesis tests, a diagnosis statement regarding what controller is most suitable to deal with the current (nominal or faulty) mode of the plant is obtained. Switching strategies that use the diagnosis statement are also proposed. This approach is applied to a nonlinear experimentally validated model of the breathing system of a polymer electrolyte membrane fuel cell. The results show the effectiveness of this FDI–fault-tolerant control data-driven methodology."
Artificial pancreas: clinical study in Latin America without premeal insulin boluses
(2018-09) Sánchez-Peña, Ricardo; Colmegna, Patricio; Garelli, Fabricio; De Battista, Hernán; García Violini, Demián; Moscoso-Vásquez, Marcela; Rosales, Nicolás; Fushimi, Emilia; Campos-Náñez, Enrique; Breton, Marc; Beruto, Valeria; Scibona, Paula; Rodriguez, Cintia; Giunta, Javier; Simonovich, Ventura; Belloso, Waldo H.; Cherñavvsky, Daniel; Grosembacher, Luis
"Background: Emerging therapies such as closed-loop (CL) glucose control, also known as artificial pancreas (AP) systems, have shown significant improvement in type 1 diabetes mellitus (T1DM) management. However, demanding patient intervention is still required, particularly at meal times. To reduce treatment burden, the automatic regulation of glucose (ARG) algorithm mitigates postprandial glucose excursions without feedforward insulin boluses. This work assesses feasibility of this new strategy in a clinical trial. Methods: A 36-hour pilot study was performed on five T1DM subjects to validate the ARG algorithm. Subjects wore a subcutaneous continuous glucose monitor (CGM) and an insulin pump. Insulin delivery was solely commanded by the ARG algorithm, without premeal insulin boluses. This was the first clinical trial in Latin America to validate an AP controller. Results: For the total 36-hour period, results were as follows: average time of CGM readings in range 70-250 mg/dl: 88.6%, in range 70-180 mg/dl: 74.7%, <70 mg/dl: 5.8%, and <50 mg/dl: 0.8%. Results improved analyzing the final 15-hour period of this trial. In that case, the time spent in range was 70-250 mg/dl: 94.7%, in range 70-180 mg/dl: 82.6%, <70 mg/dl: 4.1%, and <50 mg/dl: 0.2%. During the last night the time spent in range was 70-250 mg/dl: 95%, in range 70-180 mg/dl: 87.7%, <70 mg/dl: 5.0%, and <50 mg/dl: 0.0%. No severe hypoglycemia occurred. No serious adverse events were reported. Conclusions: The ARG algorithm was successfully validated in a pilot clinical trial, encouraging further tests with a larger number of patients and in outpatient settings."
The ARG algorithm: clinical trials in Argentina
(2019) Colmegna, Patricio; Garelli, Fabricio; De Battista, Hernán; Bianchi, Fernando D.; Sánchez-Peña, Ricardo
"The objective of this work is to present a brief review of the control design problem for glucose regulation in T1DM. In particular, control-oriented models, and robust and time-varying controllers will be mentioned. Characteristics of diabetes in general and T1DM in particular in the context of Latin America will be described. Finally, the Automatic Regulation of Glucose (ARG) algorithm will be presented, including in silico and clinical results."

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