Artículo de Publicación Periódica:
Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory

dc.contributor.authorde Landeta, Ana Belén
dc.contributor.authorMedina, Jorge Horacio
dc.contributor.authorKatche, Cynthia
dc.date.accessioned2022-11-01T15:16:55Z
dc.date.available2022-11-01T15:16:55Z
dc.date.issued2022-07-22
dc.description.abstract"The retrosplenial cortex (RSC) has been widely related to spatial and contextual memory. However, we recently demonstrated that the anterior part of the RSC (aRSC) is required for object recognition (OR) memory consolidation. In this study, we aimed to analyze the requirement of dopaminergic inputs into the aRSC for OR memory consolidation in male rats. We observed amnesia at 24-h long-term memory when we infused SCH23390, a D1/D5 dopamine receptors antagonist, into aRSC immediately after OR training session. However, the same infusion had no effect on OR short-term memory. Then, we analyzed whether the ventral tegmental area (VTA) is necessary for OR consolidation. VTA inactivation by intra-VTA administration of muscimol, a GABAA agonist, immediately after an OR training session induced amnesia when animals were tested at 24 h. Moreover, we observed that this VTA inactivation-induced amnesia was reversed by the simultaneous intra-aRSC delivery of SKF38393, a D1/D5 receptor agonist. Altogether, our results suggest that VTA dopaminergic inputs to aRSC play an important modulatory role in OR memory consolidation."
dc.identifier.issn1662-5153
dc.identifier.urihttps://ri.itba.edu.ar/handle/123456789/3952
dc.language.isoen
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnbeh.2022.922971
dc.relationinfo:eu-repo/grantAgreement/ANPCyT/PICT/2018-00762/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/CONICET/AR. Ciudad Autónoma de Buenos Aires
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/X.0/
dc.subjectDOPAMINAes
dc.subjectMEMORIAes
dc.subjectCEREBROes
dc.titleDopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
dc.typeArticle
dc.typeinfo:eu-repo/semantics/publishedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: de Landeta, Ana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: de Landeta, Ana Belén. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiationFil: Medina, Jorge Horacio. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiationFil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Medina, Jorge Horacio. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Katche, Cynthia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Katche, Cynthia. Universidad Nacional de Buenos Aires; Argentina.
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