Functional connectivity of anterior retrosplenial cortex in object  recognition memory

de Landeta, Ana Belén; Pereyra, Magdalena; Miranda, Magdalena; Bekinschtein, Pedro; Medina, Jorge Horacio; Katche, Cynthia

artículo de publicación periódica.page.titleprefix
Functional connectivity of anterior retrosplenial cortex in object recognition memory

dc.contributor.author	de Landeta, Ana Belén
dc.contributor.author	Pereyra, Magdalena
dc.contributor.author	Miranda, Magdalena
dc.contributor.author	Bekinschtein, Pedro
dc.contributor.author	Medina, Jorge Horacio
dc.contributor.author	Katche, Cynthia
dc.date	info:eu-repo/date/embargoEnd/2023-04-22
dc.date.accessioned	2022-04-13T19:55:25Z
dc.date.available	2022-04-13T19:55:25Z
dc.date.issued	2021
dc.description.abstract	"Recognition memory can rely on three components: “what”, “where” and “when”. Recently we demonstrated that the anterior retrosplenial cortex (aRSC), like the perirhinal cortex (PRH) and unlike the hippocampus (HP), is required for consolidation of the “what” component. Here, we aimed at studying which brain structures interact with the aRSC to process object recognition (OR) memory in rats. We studied the interaction of six brain structures that are connected to the aRSC during OR memory processing: PRH, medial prefrontal cortex (mPFC), anteromedial thalamic nuclei (AM), medial entorhinal cortex (MEC), anterior cingulate cortex (ACC) and the dorsal HP (dHP). We previously described the role of the PRH and dHP, so we first studied the participation of the mPFC, AM, MEC and ACC in OR memory consolidation by bilateral microinfusions of the GABAA receptor agonist muscimol. We observed an impairment in OR long-term memory (LTM) when inactivating the mPFC, the AM and the MEC, but not the ACC. Then, we studied the functional connections by unilateral inactivation of the aRSC and each one of the six structures in the same (ipsilateral) or the opposite (contralateral) hemisphere. Our results showed an amnesic LTM effect in rats with ipsilateral inactivations of aRSC-PRH, aRSC-mPFC, aRSC-AM, or aRSC-MEC. On the other hand, we observed memory impairment when aRSC-ACC were inactivated in opposite hemispheres, and no effect when the aRSC-dHP connection was inactivated. Thus, our ipsilateral inactivation findings reveal that the aRSC and, at least one brain region required in OR LTM processing are essential to consolidate OR memory. In conclusion, our results show that several cortico-cortical and cortico thalamic pathways are important for OR memory consolidation."	en
dc.identifier.issn	1074-7427
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/3777
dc.language.iso	en	en
dc.relation	info:eurepo/semantics/altIdentifier/10.1016/j.nlm.2021.107544
dc.subject	CONSOLIDACION DE LA MEMORIA	es
dc.subject	MEMORIA	es
dc.subject	GIRO DEL CINGULO	es
dc.subject	MUSCIMOL	es
dc.title	Functional connectivity of anterior retrosplenial cortex in object recognition memory	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: de Landeta, Ana Belén. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: de Landeta, Ana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
itba.description.filiation	Fil: Pereyra, Magdalena. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Pereyra, Magdalena. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Miranda, Magdalena. Universidad Favaloro; Argentina.
itba.description.filiation	Fil: Bekinschtein, Pedro. Universidad Favaloro; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Katche, Cynthia. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Katche, Cynthia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.