artículo de publicación periódica.page.titleprefix
Electropore formation in mechanically constrained phospholipid bilayers

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dc.contributor.authorFernández, María Laura
dc.contributor.authorRisk, Marcelo
dc.contributor.authorVernier, P. Thomas
dc.date.accessioned2019-04-22T20:26:25Z
dc.date.available2019-04-22T20:26:25Z
dc.date.issued2018-04
dc.description.abstract"Molecular dynamics simulations of lipid bilayers in aqueous systems reveal how an applied electric field stabilizes the reorganization of the water–membrane interface into water-filled, membrane-spanning, conductive pores with a symmetric, toroidal geometry. The pore formation process and the resulting symmetric structures are consistent with other mathematical approaches such as continuum models formulated to describe the electroporation process. Some experimental data suggest, however, that the shape of lipid electropores in living cell membranes may be asymmetric. We describe here the axially asym-metric pores that form when mechanical constraints are applied to selected phospholipid atoms. Electropore formation pro-ceeds even with severe constraints in place, but pore shape and pore formation time are affected. Since lateral and transverse movement of phospholipids may be restricted in cell membranes by covalent attachments to or non-covalent associations with other components of the membrane or to membrane-proximate intracellular or extracellular biomolecular assemblies, these lipid-constrained molecular models point the way to more realistic representations of cell membranes in electric fields."en
dc.identifier.issn0022-2631
dc.identifier.urihttp://ri.itba.edu.ar/handle/123456789/1552
dc.language.isoenen
dc.relationinfo:eu-repo/grantAgreement/AFOSR/MURI/FA9550-15-1-0517/US. Arlington, VA.
dc.relationinfo:eu-repo/grantAgreement/AFOSR/FA9550-14-1-0123/US. Arlington, VA.
dc.relationinfo:eu-repo/grantAgreement/UBA/UBACyT GC/20620130100027BA/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/CONICET/PIP GI/11220110100379/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/ITBA/ITBACyT/2015/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s00232-017-0002-y
dc.subjectDINAMICA MOLECULARes
dc.titleElectropore formation in mechanically constrained phospholipid bilayersen
dc.typeArtículos de Publicaciones Periódicases
dc.typeinfo:eu-repo/semantics/acceptedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: Fernández, María Laura. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales; Argentina.
itba.description.filiationFil: Fernández, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Risk, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Risk, Marcelo. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Vernier, P. Thomas. Old Dominion University; Estados Unidos.

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