artículo de publicación periódica.page.titleprefix
Persistence of spatial memory induced by spaced training involves a behavioral-tagging process

dc.contributor.authorCorrea, Julieta
dc.contributor.authorTintorelli, Ramiro
dc.contributor.authorBudriesi, Pablo
dc.contributor.authorViola, Haydeé
dc.date.accessioned2023-01-03T15:08:26Z
dc.date.available2023-01-03T15:08:26Z
dc.date.issued2022-08-10
dc.description.abstract"Spaced training, which involves long inter-trial intervals, has positive effects on memories. One of the main attributes of long-term memories (LTM) is persistence. Here, to identify the process that promotes LTM persistence by spaced learning, we used the spatial object recognition (SOR) task in rats. The protocol consisted of a first strong training session that induced LTM formation (tested 1 day after training), but not LTM persistence (tested 7 or 14 days after training); and a second weak training session that promoted memory persistence when applied 1 day, but not 7 days, after the first training. We propose that the promotion of memory persistence is based on the Behavioral Tagging (BT) mechanism operating when the memory trace is retrieved. BT involves the setting of a tag induced by learning which gives rise to input selectivity, and the use of plasticity-related proteins (PRPs) to establish the mnemonic trace. We postulate that retraining will mainly retag the sites initially activated by the original learning, where the PRPs needed for memory expression and/or induced by retrieval would be used to maintain a persistent mnemonic trace. Our results suggest that the mechanism of memory expression, but not those of memory reinforcement or reconsolidation, is necessary to promote memory persistence after retraining. The molecular mechanisms involve ERKs1/2 activity to set the SOR learning tag, and the availability of GluA2-containing AMPA receptor. In conclusion, both the synthesis of PRPs and the setting of learning tags are key processes triggered by retraining that allow SOR memory persistence."
dc.identifier.issn0306-4522
dc.identifier.urihttps://ri.itba.edu.ar/handle/123456789/4128
dc.language.isoen
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2022.02.032
dc.relationinfo:eu-repo/grantAgreement/ANPCyT/PICT/2016-0172/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/UBA/UBACyT/20020170100501BA/AR. Ciudad Autónoma de Buenos Aires
dc.subjectAPRENDIZAJEes
dc.subjectMEMORIAes
dc.subjectCONSOLIDACION DE LA MEMORIAes
dc.titlePersistence of spatial memory induced by spaced training involves a behavioral-tagging process
dc.typeArtículo de Publicación Periódica
dc.typeinfo:eu-repo/semantics/acceptedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: Correa, Julieta. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiationFil: Correa, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Tintorelli, Ramiro. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiationFil: Tintorelli, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Budriesi, Pablo. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiationFil: Budriesi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Viola, Haydeé. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiationFil: Viola, Haydeé. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Viola, Haydeé. Instituto Tecnológico de Buenos Aires; Argentina.

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