Persistence of spatial memory induced by spaced training involves a behavioral-tagging process

Correa, Julieta; Tintorelli, Ramiro; Budriesi, Pablo; Viola, Haydeé

Artículo de Publicación Periódica:
Persistence of spatial memory induced by spaced training involves a behavioral-tagging process

dc.contributor.author	Correa, Julieta
dc.contributor.author	Tintorelli, Ramiro
dc.contributor.author	Budriesi, Pablo
dc.contributor.author	Viola, Haydeé
dc.date.accessioned	2023-01-03T15:08:26Z
dc.date.available	2023-01-03T15:08:26Z
dc.date.issued	2022-08-10
dc.description.abstract	"Spaced training, which involves long inter-trial intervals, has positive effects on memories. One of the main attributes of long-term memories (LTM) is persistence. Here, to identify the process that promotes LTM persistence by spaced learning, we used the spatial object recognition (SOR) task in rats. The protocol consisted of a first strong training session that induced LTM formation (tested 1 day after training), but not LTM persistence (tested 7 or 14 days after training); and a second weak training session that promoted memory persistence when applied 1 day, but not 7 days, after the first training. We propose that the promotion of memory persistence is based on the Behavioral Tagging (BT) mechanism operating when the memory trace is retrieved. BT involves the setting of a tag induced by learning which gives rise to input selectivity, and the use of plasticity-related proteins (PRPs) to establish the mnemonic trace. We postulate that retraining will mainly retag the sites initially activated by the original learning, where the PRPs needed for memory expression and/or induced by retrieval would be used to maintain a persistent mnemonic trace. Our results suggest that the mechanism of memory expression, but not those of memory reinforcement or reconsolidation, is necessary to promote memory persistence after retraining. The molecular mechanisms involve ERKs1/2 activity to set the SOR learning tag, and the availability of GluA2-containing AMPA receptor. In conclusion, both the synthesis of PRPs and the setting of learning tags are key processes triggered by retraining that allow SOR memory persistence."
dc.identifier.issn	0306-4522
dc.identifier.uri	https://ri.itba.edu.ar/handle/123456789/4128
dc.language.iso	en
dc.relation	info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuroscience.2022.02.032
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2016-0172/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/UBA/UBACyT/20020170100501BA/AR. Ciudad Autónoma de Buenos Aires
dc.subject	APRENDIZAJE	es
dc.subject	MEMORIA	es
dc.subject	CONSOLIDACION DE LA MEMORIA	es
dc.title	Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
dc.type	Artículo de Publicación Periódica
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Correa, Julieta. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Correa, Julieta. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Tintorelli, Ramiro. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Tintorelli, Ramiro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Budriesi, Pablo. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Budriesi, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Viola, Haydeé. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Viola, Haydeé. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Viola, Haydeé. Instituto Tecnológico de Buenos Aires; Argentina.