Artículo de Publicación Periódica:
Memory reconsolidation as a tool to endure encoding deficits in elderly

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dc.contributor.authorTassone, Leonela M.
dc.contributor.authorUrreta Benítez, Facundo A.
dc.contributor.authorRochon, Delfina
dc.contributor.authorMartínez, Paula B.
dc.contributor.authorBonilla, Matías
dc.contributor.authorLeón, Candela S.
dc.contributor.authorMuchnik, Carolina
dc.contributor.authorSolis, Patricia
dc.contributor.authorMedel, Nancy
dc.contributor.authorKochen, Silvia
dc.contributor.authorBrusco, Luis Ignacio
dc.contributor.authorMoyano, Malen D.
dc.contributor.authorForcato, Cecilia
dc.date.accessioned2020-08-12T17:46:16Z
dc.date.available2020-08-12T17:46:16Z
dc.date.issued2020-08
dc.description.abstract"Normal aging involves changes in the ability to acquire, consolidate and recall new information. It has been recently proposed that the reconsolidation process is also affected in older adults. Reconsolidation is triggered after reminder presentation, allowing memories to be modified: they can be impaired, strengthened or changed in their content. In young adults it was previously shown that the presentation of repetitive reminders induces memory strengthening one day after reactivation and the presentation of at least one reminder increases memory persistence several days after reactivation. However, until now this process has remained elusive in older adults. We hypothesize that older adults need a stronger reminder to induce memory strengthening through the reconsolidation process than young adults. To test this, we perform a three-day experiment. On day 1, participants learned 15 sound-word associations, on day 2 they received no reminders (NR group), one reminder (R group) or two rounds of reactivations (Rx2 group). Finally, they were tested on day 7. We found that, contrary to our hypothesis, older adults show a memory improvement triggered by repeated labilization/reconsolidation processes to an equal extent than young adults. These results open new perspectives into the use of reconsolidation to improve daily acquired information and the development of therapeutic home used tools to produce memory enhancement in healthy older adults or those with cognitive decline."en
dc.identifier.issn1932-6203
dc.identifier.urihttp://ri.itba.edu.ar/handle/123456789/2479
dc.language.isoenen
dc.relationinfo:eu-repo/semantics/reference/doi.org/10.1371/journal.pone.0237361
dc.relationinfo:eu-repo/grantAgreement/ANPCyT/PICT/2016-0229/AR. Ciudad Autónoma de Buenos Aires
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectCONSOLIDACION DE LA MEMORIAes
dc.subjectEDAD ADULTAes
dc.subjectANCIANOSes
dc.subjectRECUPERACION DE INFORMACIONes
dc.titleMemory reconsolidation as a tool to endure encoding deficits in elderlyen
dc.typeArtículos de Publicaciones Periódicases
dc.typeinfo:eu-repo/semantics/publishedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: Tassone, Leonela M. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Tassone, Leonela M. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Urreta Benítez, Facundo A. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Urreta Benítez, Facundo A. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Rochon, Delfina. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Martínez, Paula B. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Bonilla, Matías. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: León, Candela S. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Muchnik, Carolina. Universidad de Buenos Aires. Facultad de Medicina; Argentina.
itba.description.filiationFil: Solis, Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Solis, Patricia. Hospital El Cruce Dr. Néstor Carlos Kirchner; Argentina.
itba.description.filiationFil: Solis, Patricia. Universidad Nacional Arturo Jauretche; Argentina.
itba.description.filiationFil: Medel, Nancy. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Medel, Nancy. Hospital El Cruce Dr. Néstor Carlos Kirchner; Argentina.
itba.description.filiationFil: Medel, Nancy. Universidad Nacional Arturo Jauretche; Argentina.
itba.description.filiationFil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Forcato, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Brusco, Luis Ignacio. Universidad de Buenos Aires; Argentina.

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