Artículo de Publicación Periódica:
Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation

dc.contributor.authorPastor, Verónica
dc.contributor.authorMedina, Jorge Horacio
dc.dateinfo:eu-repo/date/embargoEnd/2022-04-30
dc.date.accessioned2021-04-19T16:09:15Z
dc.date.available2021-04-19T16:09:15Z
dc.date.issued2021-03-04
dc.description.abstract"How does the brain guide our actions? This is a complex issue, where the medial prefrontal cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and decision making. These functions are related to reward- and aversionbased learning, which ultimately drive behavior. Though, cortical projections and modulatory systems that may regulate those processes in the mPFC are less understood. How does the mPFC regulate approach-avoidance behavior in the case of conflicting aversive and appetitive stimuli? This is likely dependent on the bottomup neuromodulation of the mPFC projection neurons. In this review, we integrate behavioral-, pharmacological-, and viral-based circuit manipulation data showing the involvement of mPFC dopaminergic, noradrenergic, cholinergic, and serotoninergic inputs in reward and aversion processing. Given that an incorrect balance of reward and aversion value could be a key problem in mental diseases such as substance use disorders, we discuss outstanding questions for future research on the role of mPFC modulation in reward and aversion."en
dc.identifier.issn1460-9568
dc.identifier.urihttp://ri.itba.edu.ar/handle/123456789/3450
dc.language.isoenen
dc.relationinformación: eu-repo/grantAgreement/FONCyT/ PICT/2016-0034/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/semantics/reference/doi.org/10.1111/ejn.15168
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectENFERMEDADES MENTALESes
dc.subjectCONDUCTAes
dc.subjectCORTEZA PREFRONTALes
dc.subjectNEURONASes
dc.subjectSEROTONINAes
dc.subjectNORADRENALINAes
dc.subjectDOPAMINAes
dc.subjectACETILCOLINAes
dc.titleMedial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulationen
dc.typeArtículos de Publicaciones Periódicases
dc.typeinfo:eu-repo/semantics/publishedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: Pastor, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Pastor, Verónica. Universidad de Buenos Aires. Facultad de Medicina; Argentina.
itba.description.filiationFil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Medina, Jorge Horacio. Instituto Tecnológico de Buenos Aires; Argentina.

Archivos

Bloque original
Mostrando 1 - 1 de 1
Cargando...
Miniatura
Nombre:
Pastor_NEUROCIENCIAS_editar.pdf
Tamaño:
1.43 MB
Formato:
Adobe Portable Document Format
Descripción:
Articulo_Pastor
Bloque de licencias
Mostrando 1 - 1 de 1
No hay miniatura disponible
Nombre:
license.txt
Tamaño:
1.6 KB
Formato:
Item-specific license agreed upon to submission
Descripción:

Colecciones