Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation

Pastor, Verónica; Medina, Jorge Horacio

artículo de publicación periódica.page.titleprefix
Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation

dc.contributor.author	Pastor, Verónica
dc.contributor.author	Medina, Jorge Horacio
dc.date	info:eu-repo/date/embargoEnd/2022-04-30
dc.date.accessioned	2021-04-19T16:09:15Z
dc.date.available	2021-04-19T16:09:15Z
dc.date.issued	2021-03-04
dc.description.abstract	"How does the brain guide our actions? This is a complex issue, where the medial prefrontal cortex (mPFC) plays a crucial role. The mPFC is essential for cognitive flexibility and decision making. These functions are related to reward- and aversionbased learning, which ultimately drive behavior. Though, cortical projections and modulatory systems that may regulate those processes in the mPFC are less understood. How does the mPFC regulate approach-avoidance behavior in the case of conflicting aversive and appetitive stimuli? This is likely dependent on the bottomup neuromodulation of the mPFC projection neurons. In this review, we integrate behavioral-, pharmacological-, and viral-based circuit manipulation data showing the involvement of mPFC dopaminergic, noradrenergic, cholinergic, and serotoninergic inputs in reward and aversion processing. Given that an incorrect balance of reward and aversion value could be a key problem in mental diseases such as substance use disorders, we discuss outstanding questions for future research on the role of mPFC modulation in reward and aversion."	en
dc.identifier.issn	1460-9568
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/3450
dc.language.iso	en	en
dc.relation	información: eu-repo/grantAgreement/FONCyT/ PICT/2016-0034/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/semantics/reference/doi.org/10.1111/ejn.15168
dc.rights	info:eu-repo/semantics/embargoedAccess
dc.subject	ENFERMEDADES MENTALES	es
dc.subject	CONDUCTA	es
dc.subject	CORTEZA PREFRONTAL	es
dc.subject	NEURONAS	es
dc.subject	SEROTONINA	es
dc.subject	NORADRENALINA	es
dc.subject	DOPAMINA	es
dc.subject	ACETILCOLINA	es
dc.title	Medial prefrontal cortical control of reward- and aversion-based behavioral output: bottom-up modulation	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Pastor, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Pastor, Verónica. Universidad de Buenos Aires. Facultad de Medicina; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Instituto Tecnológico de Buenos Aires; Argentina.