The effect of zolpidem on targeted memory reactivation during sleep

Carbone, Julia; Bibián, Carlos; Reischl, Patrick; Born, Jan; Forcato, Cecilia; Diekelmann, Susanne

Artículo de Publicación Periódica:
The effect of zolpidem on targeted memory reactivation during sleep

dc.contributor.author	Carbone, Julia
dc.contributor.author	Bibián, Carlos
dc.contributor.author	Reischl, Patrick
dc.contributor.author	Born, Jan
dc.contributor.author	Forcato, Cecilia
dc.contributor.author	Diekelmann, Susanne
dc.date.accessioned	2022-12-15T18:39:50Z
dc.date.available	2022-12-15T18:39:50Z
dc.date.issued	2021
dc.description.abstract	"According to the active system consolidation theory, memory consolidation during sleep relies on the reactivation of newly encoded memory representations. This reactivation is orchestrated by the interplay of sleep slow oscillations, spindles, and theta, which are in turn modulated by certain neurotransmitters like GABA to enable long-lasting plastic changes in the memory store. Here we asked whether the GABAergic system and associated changes in sleep oscillations are functionally related to memory reactivation during sleep. We administered the GABAA agonist zolpidem (10 mg) in a double-blind placebo-controlled study. To specifically focus on the effects on memory reactivation during sleep, we experimentally induced such reactivations by targeted memory reactivation (TMR) with learning-associated reminder cues presented during post-learning slow-wave sleep (SWS). Zolpidem significantly enhanced memory performance with TMR during sleep compared with placebo. Zolpidem also increased the coupling of fast spindles and theta to slow oscillations, although overall the power of slow spindles and theta was reduced compared with placebo. In an uncorrected exploratory analysis, memory performance was associated with slow spindle responses to TMR in the zolpidem condition, whereas it was asso ciated with fast spindle responses in placebo. These findings provide tentative first evidence that GABAergic activity may be functionally implicated in memory reactivation processes during sleep, possibly via its effects on slow oscillations, spindles and theta as well as their interplay."
dc.identifier.issn	1072-0502
dc.identifier.uri	https://ri.itba.edu.ar/handle/123456789/4089
dc.language.iso	en
dc.relation	info:eu-repo/semantics/reference/doi/10.1101/lm.052787.120.
dc.subject	CONSOLIDACION DE LA MEMORIA	es
dc.title	The effect of zolpidem on targeted memory reactivation during sleep
dc.type	info:eu-repo/semantics/publishedVersion
dc.type	Artículo de Publicación Periódica	es
dc.type	SUEÑO Y MEMORIA	es
dc.type	APRENDIZAJE	es
dspace.entity.type	Artículo de Publicación Periódica	es
itba.description.filiation	Fil: Carbone, Julia. Eberhard Karls Universität Tübingen; Alemania.
itba.description.filiation	Fil: Carbone, Julia. International Max Planck Research Schools; Alemania.
itba.description.filiation	Fil: Bibián, Carlos. Eberhard Karls Universität Tübingen; Alemania.
itba.description.filiation	Fil: Bibián, Carlos. International Max Planck Research Schools; Alemania.
itba.description.filiation	Fil: Reischl, Patrick. Eberhard Karls Universität Tübingen; Alemania.
itba.description.filiation	Fil: Born, Jan. Eberhard Karls Universität Tübingen; Alemania.
itba.description.filiation	Fil: Born, Jan. Werner Reichardt Centre for Integrative Neuroscience; Alemania.
itba.description.filiation	Fil: Born, Jan. Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich, Alemania.
itba.description.filiation	Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Forcato, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Diekelmann, Susanne. Eberhard Karls Universität Tübingen; Alemania.
itba.description.filiation	Fil: Diekelmann, Susanne. Department of Psychiatry and Psychotherapy; Alemania.