Artículo de Publicación Periódica:
Artificial pancreas: clinical study in Latin America without premeal insulin boluses

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dc.contributor.authorSánchez-Peña, Ricardo
dc.contributor.authorColmegna, Patricio
dc.contributor.authorGarelli, Fabricio
dc.contributor.authorDe Battista, Hernán
dc.contributor.authorGarcía Violini, Demián
dc.contributor.authorMoscoso-Vásquez, Marcela
dc.contributor.authorRosales, Nicolás
dc.contributor.authorFushimi, Emilia
dc.contributor.authorCampos-Náñez, Enrique
dc.contributor.authorBreton, Marc
dc.contributor.authorBeruto, Valeria
dc.contributor.authorScibona, Paula
dc.contributor.authorRodriguez, Cintia
dc.contributor.authorGiunta, Javier
dc.contributor.authorSimonovich, Ventura
dc.contributor.authorBelloso, Waldo H.
dc.contributor.authorCherñavvsky, Daniel
dc.contributor.authorGrosembacher, Luis
dc.coverage.spatialAmérica Latinaes
dc.date.accessioned2019-07-15T20:16:23Z
dc.date.available2019-07-15T20:16:23Z
dc.date.issued2018-09
dc.description.abstract"Background: Emerging therapies such as closed-loop (CL) glucose control, also known as artificial pancreas (AP) systems, have shown significant improvement in type 1 diabetes mellitus (T1DM) management. However, demanding patient intervention is still required, particularly at meal times. To reduce treatment burden, the automatic regulation of glucose (ARG) algorithm mitigates postprandial glucose excursions without feedforward insulin boluses. This work assesses feasibility of this new strategy in a clinical trial. Methods: A 36-hour pilot study was performed on five T1DM subjects to validate the ARG algorithm. Subjects wore a subcutaneous continuous glucose monitor (CGM) and an insulin pump. Insulin delivery was solely commanded by the ARG algorithm, without premeal insulin boluses. This was the first clinical trial in Latin America to validate an AP controller. Results: For the total 36-hour period, results were as follows: average time of CGM readings in range 70-250 mg/dl: 88.6%, in range 70-180 mg/dl: 74.7%, <70 mg/dl: 5.8%, and <50 mg/dl: 0.8%. Results improved analyzing the final 15-hour period of this trial. In that case, the time spent in range was 70-250 mg/dl: 94.7%, in range 70-180 mg/dl: 82.6%, <70 mg/dl: 4.1%, and <50 mg/dl: 0.2%. During the last night the time spent in range was 70-250 mg/dl: 95%, in range 70-180 mg/dl: 87.7%, <70 mg/dl: 5.0%, and <50 mg/dl: 0.0%. No severe hypoglycemia occurred. No serious adverse events were reported. Conclusions: The ARG algorithm was successfully validated in a pilot clinical trial, encouraging further tests with a larger number of patients and in outpatient settings."en
dc.identifier.issn1932-2968
dc.identifier.urihttp://ri.itba.edu.ar/handle/123456789/1653
dc.language.isoenen
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1177/1932296818786488
dc.relationinfo:eu-repo/grantAgreement/CONICET/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/UNLP/AR. Buenos Aires. La Plata
dc.relationinfo:eu-repo/grantAgreement/UNQ/AR. Buenos Aires. Bernal
dc.relationinfo:eu-repo/grantAgreement/ITBA/AR. Ciudad Autónoma de Buenos Aires
dc.relationinfo:eu-repo/grantAgreement/JDRF/SRA/2-SRA-2016-291-Q-R/US. Nueva York, NY
dc.subjectPANCREASes
dc.subjectORGANOS ARTIFICIALESes
dc.subjectDIABETESes
dc.subjectINSULINAes
dc.subjectENSAYOS CLINICOSes
dc.subjectCONTROL EN MODO DESLIZANTEes
dc.subjectGLUCOSAes
dc.titleArtificial pancreas: clinical study in Latin America without premeal insulin bolusesen
dc.typePonencias en Congresoses
dc.typeinfo:eu-repo/semantics/acceptedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: Sánchez-Peña, Ricardo. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Sánchez-Peña, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Colmegna, Patricio. Universidad Nacional de Quilmes; Argentina.
itba.description.filiationFil: Colmegna, Patricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Colmegna, Patricio. University of Virginia; Estados Unidos.
itba.description.filiationFil: Garelli, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Garelli, Fabricio. Universidad Nacional de La Plata; Argentina.
itba.description.filiationFil: De Battista, Hernán. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: De Battista, Hernán. Universidad Nacional de La Plata; Argentina.
itba.description.filiationFil: García-Violini, Demián. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: García Violini, Demián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Moscoso-Vásquez, Marcela. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiationFil: Moscoso-Vásquez, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Rosales, Nicolás. Universidad Nacional de La Plata; Argentina.
itba.description.filiationFil: Fushimi, Emilia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiationFil: Fushimi, Emilia. Universidad Nacional de La Plata; Argentina.
itba.description.filiationFil: Campos-Náñez, Enrique. TypeZero Technologies; Estados Unidos.
itba.description.filiationFil: Breton, Marc. University of Virginia; Estados Unidos.
itba.description.filiationFil: Beruto, Valeria. Hospital Italiano de Buenos Aires; Argentina.
itba.description.filiationFil: Scibona, Paula. Hospital Italiano de Buenos Aires; Argentina.
itba.description.filiationFil: Rodriguez, Cintia. Hospital Italiano de Buenos Aires; Argentina.
itba.description.filiationFil: Giunta, Javier. Hospital Italiano de Buenos Aires; Argentina.
itba.description.filiationFil: Simonovich, Ventura. Hospital Italiano de Buenos Aires; Argentina.
itba.description.filiationFil: Belloso, Waldo H. Hospital Italiano de Buenos Aires; Argentina.
itba.description.filiationFil: Cherñavvsky, Daniel. Hospital Italiano de Buenos Aires; Argentina.
itba.description.filiationFil: Grosembacher, Luis. Hospital Italiano de Buenos Aires; Argentina.

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