Volume-conducted origin of the field potential at the lateral habenula

Bertone-Cueto, Nicolás I.; Makarova, Julia; Mosqueira, Alejo; García Violini, Demián; Sánchez-Peña, Ricardo; Herreras, Oscar; Belluscio, Mariano; Piriz, Joaquín

Artículo de Publicación Periódica:
Volume-conducted origin of the field potential at the lateral habenula

dc.contributor.author	Bertone-Cueto, Nicolás I.
dc.contributor.author	Makarova, Julia
dc.contributor.author	Mosqueira, Alejo
dc.contributor.author	García Violini, Demián
dc.contributor.author	Sánchez-Peña, Ricardo
dc.contributor.author	Herreras, Oscar
dc.contributor.author	Belluscio, Mariano
dc.contributor.author	Piriz, Joaquín
dc.date.accessioned	2020-03-23T21:51:16Z
dc.date.available	2020-03-23T21:51:16Z
dc.date.issued	2020-01
dc.description.abstract	"Field potentials (FPs) are easily reached signals that provide information about the brain’s processing. However, FP should be interpreted cautiously since their biophysical bases are complex. The lateral habenula (LHb) is a brain structure involved in the encoding of aversive motivational values. Previous work indicates that the activity of the LHb is relevant for hippocampal-dependent learning. Moreover, it has been proposed that the interaction of the LHb with the hippocampal network is evidenced by the synchronization of LHb and hippocampal FPs during theta rhythm. However, the origin of the habenular FP has not been analyzed. Hence, its validity as a measurement of LHb activity has not been proven. In this work, we used electrophysiological recordings in anesthetized rats and feed-forward modeling to investigate biophysical basis of the FP recorded in the LHb. Our results indicate that the FP in the LHb during theta rhythm is a volume-conducted signal from the hippocampus. This result highlight that FPs must be thoroughly analyzed before its biological interpretation and argues against the use of the habenular FP signal as a readout of the activity of the LHb."	en
dc.identifier.issn	1662-5137
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/1912
dc.language.iso	en	en
dc.relation	info:eu-repo/semantics/reference/doi/10.3389/fnsys.2019.00078
dc.relation	info:eu-repo/grantAgreement/BBRF/YI 2015/#23861/US. Nueva York
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2015-2609/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2017-4594/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2016-0396/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/ UBA/UBACyT/2018/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2017-2417/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/MINECO/PEIDIORS/SAF2016-80100-R/SP. Madrid
dc.rights	https://creativecommons.org/licenses/by/4.0/
dc.subject	CEREBRO	es
dc.subject	FISIOLOGIA HUMANA	es
dc.title	Volume-conducted origin of the field potential at the lateral habenula	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Bertone-Cueto, Nicolás I. Universidad de Buenos Aires. Facultad de Medicina; Argentina.
itba.description.filiation	Fil: Bertone-Cueto, Nicolás I. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Makarova, Julia. Consejo Superior de Investigaciones Científicas; España.
itba.description.filiation	Fil: Mosqueira, Alejo. Universidad de Buenos Aires. Facultad de Medicina; Argentina.
itba.description.filiation	Fil: Mosqueira, Alejo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: García Violini, Demián. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: García Violini, Demián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Sánchez-Peña, Ricardo. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Sánchez-Peña, Ricardo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Herreras, Oscar. Consejo Superior de Investigaciones Científicas; España.
itba.description.filiation	Fil: Belluscio, Mariano. Universidad de Buenos Aires. Facultad de Medicina; Argentina.
itba.description.filiation	Fil: Belluscio, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Piriz, Joaquín. Universidad de Buenos Aires. Facultad de Medicina; Argentina.
itba.description.filiation	Fil: Piriz, Joaquín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.