Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory

de Landeta, Ana Belén; Medina, Jorge Horacio; Katche, Cynthia

artículo de publicación periódica.page.titleprefix
Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory

dc.contributor.author	de Landeta, Ana Belén
dc.contributor.author	Medina, Jorge Horacio
dc.contributor.author	Katche, Cynthia
dc.date.accessioned	2022-11-01T15:16:55Z
dc.date.available	2022-11-01T15:16:55Z
dc.date.issued	2022-07-22
dc.description.abstract	"The retrosplenial cortex (RSC) has been widely related to spatial and contextual memory. However, we recently demonstrated that the anterior part of the RSC (aRSC) is required for object recognition (OR) memory consolidation. In this study, we aimed to analyze the requirement of dopaminergic inputs into the aRSC for OR memory consolidation in male rats. We observed amnesia at 24-h long-term memory when we infused SCH23390, a D1/D5 dopamine receptors antagonist, into aRSC immediately after OR training session. However, the same infusion had no effect on OR short-term memory. Then, we analyzed whether the ventral tegmental area (VTA) is necessary for OR consolidation. VTA inactivation by intra-VTA administration of muscimol, a GABAA agonist, immediately after an OR training session induced amnesia when animals were tested at 24 h. Moreover, we observed that this VTA inactivation-induced amnesia was reversed by the simultaneous intra-aRSC delivery of SKF38393, a D1/D5 receptor agonist. Altogether, our results suggest that VTA dopaminergic inputs to aRSC play an important modulatory role in OR memory consolidation."
dc.identifier.issn	1662-5153
dc.identifier.uri	https://ri.itba.edu.ar/handle/123456789/3952
dc.language.iso	en
dc.relation	info:eu-repo/semantics/altIdentifier/doi/10.3389/fnbeh.2022.922971
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2018-00762/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/CONICET/AR. Ciudad Autónoma de Buenos Aires
dc.rights	http://creativecommons.org/licenses/by-nc-sa/X.0/
dc.subject	DOPAMINA	es
dc.subject	MEMORIA	es
dc.subject	CEREBRO	es
dc.title	Dopamine D1/D5 receptors in the restrosplenial cortex are necessary to consolidate object recognition memory
dc.type	Article
dc.type	info:eu-repo/semantics/publishedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: de Landeta, Ana Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: de Landeta, Ana Belén. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Universidad Nacional de Buenos Aires; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Medina, Jorge Horacio. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Katche, Cynthia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Katche, Cynthia. Universidad Nacional de Buenos Aires; Argentina.