Examinando por Materia "OPTOGENETICA"
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Proyecto final de Grado Sistema de fotometría de fibra óptica para registrar actividad neuronal en animales en libre movimiento(2021) Chiesa Docampo, Franco; Piriz, Joaquín"El objetivo de este trabajo es presentar la investigación y desarrollo de un sistema cuyo fin es registrar por medios ópticos la actividad poblacional de neuronas identificables genéticamente. Se trata de una iniciativa conjunta para armar un equipo de fácil uso y mantenimiento. Detallando su forma de instalación, calibración y funcionamiento."Artículo de Publicación Periódica Towards an experimental control of neural activity: The Wilson-Cowan model(IFAC-PapersOnLine, 2022) Martinez, Sebastián; Sánchez-Peña, Ricardo; Belluscio, Mariano; Piriz, Joaquín; Garcia-Violini, DemiánThe prospect of modifying neural activity in a principled way, could facilitate the understanding of brain functions and the development of medical treatments. To predict the dynamics that underlie the different brain activities, several neurobiological models have been proposed, either focusing on individual cells or whole populations. In this context, control systems are a powerful tool to provide a correct articulation between inputs, i.e. neural stimuli, and observables, i.e. system outcomes. Based on well-established neurobiological hypotheses, this study presents a control framework to regulate a neural-mass activity, with potential uses for pattern tracking, such as, rhythm evoking and phase synchronisation. Being these mechanisms closely connected with real brain computations, this study is carried out using a meaningful perspective in terms of biological interpretation. To this end, the Wilson-Cowan model is used, where the input stimuli is elicited through light signals applied to genetically modified neurons that express light-gated actuators. Thus, this study states a crucial proof of concept towards a future experimental application of the control framework for neurobiological systems.