Artículos de publicaciones periódicas

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Differential neurophysiological correlates of retrieval of consolidated and reconsolidated memories in humans: an ERP and pupillometry study
(2020-10) Campos-Arteaga, G.; Forcato, Cecilia; Wainstein, G.; Lagos, R.; Palacios-García, I.; Artigas, C.; Morales, R.; Pedreira, María Eugenia; Rodríguez, E.
"Consolidated memories can return to a labile state if they are reactivated by unpredictable reminders. To persist, active memories must be re-stabilized through a process known as reconsolidation. Although there is consistent behavioral evidence about this process in humans, the retrieval process of reconsolidated memories remains poorly understood. In this context, one fundamental question is whether the same or different neurophysiological mechanisms are involved in retrieval of consolidated and reconsolidated memories. Because it has been demonstrated that the exposure to the reconsolidation process may restructure and strengthen memories, we hypothesized distinct neurophysiological patterns during retrieval of reconsolidated memories. In addition, we hypothesized that interfering with the reconsolidation process using a new learning can prevent these neurophysiological changes. To test it, consolidated, reconsolidated and declarative memories whose reconsolidation process was interfered (i.e., picture-word pairs) were evaluated in humans in an old/new associative recall task while the brain activity and the pupillary response were recorded using electroencephalography and eyetracking. Our results showed that retrieval of reconsolidated memories elicits specific patterns of brain activation, characterized by an earlier peak latency and a smaller magnitude of the left parietal ERP old/new effect compared to memories that were only consolidated or whose reconsolidation process was interfered by a new learning. Moreover, our results demonstrated that only retrieval of reconsolidated memories is associated with a late reversed mid-frontal effect in a 600–690 time window. Complementarily, memories that were reactivated showed an earlier peak latency of the pupil old/new effect compared to non-reactivated memories. These findings support the idea that reconsolidation has an important impact in how memories are retrieved in the future, showing that retrieval of reconsolidated memories is partially supported by specific brain mechanisms."
Learning new words: memory reactivation as a mechanism for strengthening and updating a novel word´s meaning
(2020-12) Laurino, Julieta; Forcato, Cecilia; Coaker, Nicole; Pedreira, María Eugenia; Kaczer, Laura
"In the present study we explored the post-learning changes in a novel word’s definition using a cue-induced memory reactivation. Native speakers of Spanish (N=373) learned low-frequency words with their corresponding definitions. The following day, reactivated groups were exposed to a reminder and provided a subjective assessment of reactivation for each word, while control groups did not receive a reactivation. Study A demonstrated that memory reactivation enhances both explicit recall and semantic integration of new meanings. Study B investigated the effect of memory reactivation in the modification of the new meanings, through three different experiments. Results show an improvement of the updated definitions according to each word´s reactivation strength. In addition, congruence with previous knowledge was found to be a boundary condition, while consolidation time had a positive modulatory effect. Our findings call attention to reactivation as a factor allowing for malleability as well as persistence of long-term memories for words."
Persistence of spatial memory induced by spaced training involves a behavioral-tagging process
(2022-08-10) Correa, Julieta; Tintorelli, Ramiro; Budriesi, Pablo; Viola, Haydeé
"Spaced training, which involves long inter-trial intervals, has positive effects on memories. One of the main attributes of long-term memories (LTM) is persistence. Here, to identify the process that promotes LTM persistence by spaced learning, we used the spatial object recognition (SOR) task in rats. The protocol consisted of a first strong training session that induced LTM formation (tested 1 day after training), but not LTM persistence (tested 7 or 14 days after training); and a second weak training session that promoted memory persistence when applied 1 day, but not 7 days, after the first training. We propose that the promotion of memory persistence is based on the Behavioral Tagging (BT) mechanism operating when the memory trace is retrieved. BT involves the setting of a tag induced by learning which gives rise to input selectivity, and the use of plasticity-related proteins (PRPs) to establish the mnemonic trace. We postulate that retraining will mainly retag the sites initially activated by the original learning, where the PRPs needed for memory expression and/or induced by retrieval would be used to maintain a persistent mnemonic trace. Our results suggest that the mechanism of memory expression, but not those of memory reinforcement or reconsolidation, is necessary to promote memory persistence after retraining. The molecular mechanisms involve ERKs1/2 activity to set the SOR learning tag, and the availability of GluA2-containing AMPA receptor. In conclusion, both the synthesis of PRPs and the setting of learning tags are key processes triggered by retraining that allow SOR memory persistence."

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