Browsing by Author "Moncada, Diego"

Now showing 1 - 3 of 3
  • Thumbnail Image
    artículo de publicación periódica.listelement.badge
    Behavioral tagging underlies memory reconsolidation
    (2020-07) Rabinovich Orlandi, Iván; Fullio, Camila L.; Schroeder, Matías Nicolás; Giurfa, Martin; Ballarini, Fabricio; Moncada, Diego
    "Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate that a memory retrieving event sets a neural tag, which enables the reconsolidation of memory after binding proteins provided by the original or a different contiguous experience. We characterized the specific temporal window during which this association is effective and identified the protein kinase A (PKA) and the extracellular signalregulated kinase 1 and 2 (ERK 1/2) pathways as the mechanisms related to the setting of the reconsolidation tag and the synthesis of proteins. Our results show, therefore, that memory reconsolidation is mediated by a “behavioral tagging” process, which is common to different memory forms. They represent a significant advance in understanding the fate of memories reconsolidated while being adjacent to other events, and provide a tool for designing noninvasive strategies to attenuate (pathological/traumatic) or improve (education-related) memories. "
  • Thumbnail Image
    artículo de publicación periódica.listelement.badge
    Second wave of COVID-19 pandemic in Argentinian population: vaccination is associated with a decrease in depressive symptoms
    (2022-06) Benedetti, Pedro; Barbuzza, Alejo; Moscato, Franco; Reppucci, Victoria; Goyeneche, Celina; Katche, Cynthia; Medina, Jorge Horacio; Viola, Haydeé; Ballarini, Fabricio; Moncada, Diego
    "Since the irruption of the coronavirus disease 2019 (COVID-19) the planet has submerged in a time of concern and uncertainty, with a direct impact on people's mental health. Moreover, the recurrent outbreaks that periodically harry different regions of the world constantly refocus people's concerns to the pandemic. Yet, each new wave heats the diverse countries in different situations, including the advances in their vaccination campaigns. In this research, we studied the levels of the general anxiety disorder (GAD) and depression in the Argentine population across the first and second waves of infections that occurred in our country."
  • Thumbnail Image
    artículo de publicación periódica.listelement.badge
    The impact of the succesive outbreaks of COVID-19, vaccination, and physical activity on mental health in the argentine population : a repeated cross-sectional study
    (2024-02-26) Barbuzza, Alejo Ramiro; Ballarini, Fabricio; Goyeneche, Celina; Reppucci, Victoria; Benedetti, Pedro; Moscato, Franco; Medina, Jorge H.; Katche, Cynthia; Moncada, Diego; Viola, Haydeé
    A controversy regarding the duration of generalized anxiety disorders (GAD) and depressive symptoms during the COVID-19 pandemic arose, stating that these symptoms last a short time, perhaps a few months, or that they are more persistent over time. After more than three years of the pandemic, this is still a question that requires an answer. The main goal of this work was to record the levels of self-perceived GAD and depression in the Argentine population at several time points during the pandemic to characterize whether they were transient or persisted over the successive waves of contagion. Furthermore, we studied the association between anti-COVID-19 vaccination and the high frequency of physical activity with GAD and depression levels to evaluate a possible protective role of these factors on mental health.