Browsing by Author "Mollica, Juan"

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    An arbitrary order Mixed Virtual Element formulation for coupled multi-dimensional flow problems
    (2022-03) Benedetto, Matías Fernando; Borio, Andrea; Kyburg, Felix E.; Scialò, Stefano; Mollica, Juan
    "Discrete Fracture and Matrix (DFM) models describe fractured porous media as complex sets of 2D planar polygons embedded in a 3D matrix representing the surrounding porous medium. The numerical simulation of the flow in a DFM requires the discretization of partial differential equations on the three dimensional matrix, the planar fractures and the one dimensional fracture intersections, and suitable coupling conditions between entities of different dimensionality need to be added at the various interfaces to close the problem. The present work proposes an arbitrary order implementation of the Virtual Element method in mixed formulation for such multidimensional problems. Details on effective strategies for mesh generation are discussed and implementation aspects are addressed. Several numerical results in various contexts are provided, which showcase the applicability of the method to flow simulations in complex multidimensional domains."
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    Field Evaluation of Novel Spatial Repellent Controlled Release Devices (CRDs) against Mosquitoes in an Outdoor Setting in the Northern Peruvian Amazon
    (Tropical Medicine and Infectious Disease, 7(11), 372. MDPI AG, 2022) Flores-Mendoza, Carmen; López-Sifuentes, Victor M.; Vásquez, Gissella M.; Stoops, Craig A.; Fisher, Michael L.; Bernier, Ulrich R.; Perry, Melynda; Mollica, Juan; Coltzau, Damián A.; Gurman, Pablo; D’hers, Sebastián; Elman, Noel M.
    U.S. military troops are exposed to mosquito-borne pathogens when deployed to endemic regions. Personal protective measures such as permethrin-treated uniforms and dermal repellents are the cornerstones of mosquito-borne disease prevention for the U.S. military. These measures have limitations and additional personal protection tools, such as spatial repellent devices to decrease the risk of vector-borne pathogen transmission, are required. Novel spatial repellent controlled-release devices formulated with metofluthrin were evaluated in an outdoor setting in the northern Amazon of Peru to evaluate performance under field conditions. The metofluthrin emitting devices lowered the number of mosquitoes captured in protected human landing collections (HLC) compared to blank devices, although there were effect differences between Anopheles spp. and species in other mosquito genera. A computational-experimental model was developed to correlate HLC and active ingredient (AI) concentrations as a function of time and space. Results show a strong correlation between the released AI and the decrease in HLC. This model represents the first effort to obtain a predictive analytical tool on device performance using HLC as the entomological endpoint.