Browsing by Author "Kaczer, Laura"
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póster.listelement.badge Declarative memory consolidation dynamics: new time windows and its implications for clinical application(2020) Moyano, Malen D.; Bonilla, Matías; Blanco, Marcelo F.; Brusco, Luis Ignacio; Pedreira, María Eugenia; Kaczer, Laura; Forcato, Cecilia"After encoding, memories go through a labile state followed by a stabilization process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder (cue) of the original memory, followed by a period of re-stabilization (reconsolidation). In both processes, once stabilization/re-stabilization is accomplished the memory cannot be modified. Currently there are studies that show a rapid stabilization after 30 min, while others studies show that stabilization occurs after 6h. However, there are no studies evaluating short and long delays simultaneously. Knowing that there are spontaneous waves of destabilization (without the re-exposure to keys linked to learning) on which the consolidation and memory persistence depend, here we investigate whether declarative memories in humans suffer spontaneous labilization/stabilization processes after learning or if they only pass through a single time window of lability."artículo de publicación periódica.listelement.badge Learning new words: memory reactivation as a mechanism for strengthening and updating a novel word´s meaning(2020-12) Laurino, Julieta; Forcato, Cecilia; Coaker, Nicole; Pedreira, María Eugenia; Kaczer, Laura"In the present study we explored the post-learning changes in a novel word’s definition using a cue-induced memory reactivation. Native speakers of Spanish (N=373) learned low-frequency words with their corresponding definitions. The following day, reactivated groups were exposed to a reminder and provided a subjective assessment of reactivation for each word, while control groups did not receive a reactivation. Study A demonstrated that memory reactivation enhances both explicit recall and semantic integration of new meanings. Study B investigated the effect of memory reactivation in the modification of the new meanings, through three different experiments. Results show an improvement of the updated definitions according to each word´s reactivation strength. In addition, congruence with previous knowledge was found to be a boundary condition, while consolidation time had a positive modulatory effect. Our findings call attention to reactivation as a factor allowing for malleability as well as persistence of long-term memories for words."artículo de publicación periódica.listelement.badge Non-linear susceptibility to interferences in declarative memory formation(2022-06-29) Moyano, Malen D.; Carbonari, Giulia; Bonilla, Matías; Pedreira, María Eugenia; Brusco, Luis Ignacio; Kaczer, Laura; Forcato, Cecilia"After encoding, memories go through a labile state followed by a stabilization process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder of the original memory, followed by a period of re-stabilization (reconsolidation). During these periods of lability the memory traces can be modified. Currently, some studies show a rapid stabilization after 30 min, while others show that stabilization occurs after longer periods (e.g. > 6 h). Here we investigate the effect of an interference treatment on declarative memory consolidation, comparing distinct time intervals after acquisition. On day 1, participants learned a list of non- syllable pairs (List 1). 5 min, 30 min, 3 h or 8 h later, they received an interference list (List 2) that acted as an amnesic agent. On day 2 (48 h after training) participants had to recall List 1 first, followed by List 2. We found that the List 1 memory was susceptible to interference when List 2 was administered 5 min or 3 h after learning but not when it was administered 30 min or 8 h after. We propose the possibility that this rapid memory protection could be induced by a fast and transient neocortical integration. Our results open a discussion about the contribution of molecular and systemic aspects to memory consolidation."póster.listelement.badge Non-linear susceptibility to interferences in declarative memory formation(2021) Moyano, Malen D.; Carbonari, Giulia; Bonilla, Matías; Brusco, Luis Ignacio; Pedreira, María Eugenia; Kaczer, Laura; Forcato, Cecilia"After encoding, memories are in a labile state followed by a stabilization process known as consolidation. Once consolidated they can enter a new labile state after the presentation of a reminder (cue) of the original memory, followed by a period of re-stabilization (reconsolidation). In both processes, once stabilization/re-stabilization is accomplished the memory cannot be modified. Currently there are studies that show a rapid stabilization after 30 min, while others studies show that stabilization occurs after 6h. However, there are no studies evaluating short and long delays simultaneously. Knowing that there are spontaneous waves of destabilization (without the re-exposure to keys linked to learning) on which the consolidation and memory persistence depends, here we investigate whether declarative memories in humans go through spontaneous abilization/stabilization processes after learning or if they only pass through a single time window of lability."póster.listelement.badge Role of dream content in memory processing during sleep: Preliminary setup(2021) Pretel, Matías; Herrero, Nerea; Fernández Sande, Joaquín; Brusco, Luis Ignacio; Ramele, Rodrigo; Kaczer, Laura; Forcato, Cecilia"After acquisition memories are in a labile state followed by a period of stabilization known as consolidation. This process is particularly favored by sleep, where the new information is spontaneously reactivated in the hippocampus, transferred and redistributed in neocortical networks facilitating long term consolidation. Also, during sleep, specifically during REM sleep, new memories are integrated into the stored information. From a neuroscientific perspective, dream content is proposed to be a consequence of the memory processes that occur during sleep. Thus, the incorporation of elements about the learned tasks during wakefulness in the content of a dream, can predict the performance of the task after sleep. Here, we developed a new paradigm to study whether dream content related to a new word learning task correlates with consolidation of new words and integration into the pre-existed semantic networks."póster.listelement.badge Word learning and semantic integration: memory reactivation as a key mechanism for building the mental lexicon(2020) Laurino, Julieta; Forcato, Cecilia; Pedreira, María Eugenia; Kaczer, Laura"Analyze the contribution of memory reactivation to the enhancement and updating of words’ meaning. Our hypothesis is that reactivating a novel word´s meaning could be a key mechanism for its lexical integration and plasticity."