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Browsing Neurociencias by Author "Carbone, Julia"
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póster.listelement.badge Cued memory reactivation is more effective during slow wave sleep than sleep stage 2(2020) Carbone, Julia; Forcato, Cecilia; Born, Jan; Diekelmann, Susanne"Compare cued memory reactivation during Slow Wave Sleep (SWS) and sleep Stage 2 (S2)."artículo de publicación periódica.listelement.badge Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans(2020-12-04) Forcato, Cecilia; Klinzing, Jens G.; Carbone, Julia; Radloff, Michael; Weber, Frederik D.; Born, Jan; Diekelmann, Susanne"Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection."artículo de publicación periódica.listelement.badge The effect of zolpidem on targeted memory reactivation during sleep(2021) Carbone, Julia; Bibián, Carlos; Reischl, Patrick; Born, Jan; Forcato, Cecilia; Diekelmann, Susanne"According to the active system consolidation theory, memory consolidation during sleep relies on the reactivation of newly encoded memory representations. This reactivation is orchestrated by the interplay of sleep slow oscillations, spindles, and theta, which are in turn modulated by certain neurotransmitters like GABA to enable long-lasting plastic changes in the memory store. Here we asked whether the GABAergic system and associated changes in sleep oscillations are functionally related to memory reactivation during sleep. We administered the GABAA agonist zolpidem (10 mg) in a double-blind placebo-controlled study. To specifically focus on the effects on memory reactivation during sleep, we experimentally induced such reactivations by targeted memory reactivation (TMR) with learning-associated reminder cues presented during post-learning slow-wave sleep (SWS). Zolpidem significantly enhanced memory performance with TMR during sleep compared with placebo. Zolpidem also increased the coupling of fast spindles and theta to slow oscillations, although overall the power of slow spindles and theta was reduced compared with placebo. In an uncorrected exploratory analysis, memory performance was associated with slow spindle responses to TMR in the zolpidem condition, whereas it was asso ciated with fast spindle responses in placebo. These findings provide tentative first evidence that GABAergic activity may be functionally implicated in memory reactivation processes during sleep, possibly via its effects on slow oscillations, spindles and theta as well as their interplay."