artículo de publicación periódica.page.titleprefix
Behavioral tagging underlies memory reconsolidation

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dc.contributor.authorRabinovich Orlandi, Iván
dc.contributor.authorFullio, Camila L.
dc.contributor.authorSchroeder, Matías Nicolás
dc.contributor.authorGiurfa, Martin
dc.contributor.authorBallarini, Fabricio
dc.contributor.authorMoncada, Diego
dc.dateinfo:eu-repo/date/embargoEnd/2020-02-01
dc.date.accessioned2020-10-28T15:50:27Z
dc.date.available2020-10-28T15:50:27Z
dc.date.issued2020-07
dc.description.abstract"Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate that a memory retrieving event sets a neural tag, which enables the reconsolidation of memory after binding proteins provided by the original or a different contiguous experience. We characterized the specific temporal window during which this association is effective and identified the protein kinase A (PKA) and the extracellular signalregulated kinase 1 and 2 (ERK 1/2) pathways as the mechanisms related to the setting of the reconsolidation tag and the synthesis of proteins. Our results show, therefore, that memory reconsolidation is mediated by a “behavioral tagging” process, which is common to different memory forms. They represent a significant advance in understanding the fate of memories reconsolidated while being adjacent to other events, and provide a tool for designing noninvasive strategies to attenuate (pathological/traumatic) or improve (education-related) memories. "en
dc.identifier.issn0027-8424
dc.identifier.urihttp://ri.itba.edu.ar/handle/123456789/3217
dc.language.isoenen
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1073/pnas.2009517117
dc.relationinfo:eu-repo/grantAgreement/ANPCyT/PICT/2015-2320/AR. Ciudad Autónoma de Buenos Aires
dc.rightsinfo:eu-repo/semantics/embargoedAccess
dc.subjectCONSOLIDACION DE LA MEMORIAes
dc.subjectETIQUETADO CONDUCTUALes
dc.titleBehavioral tagging underlies memory reconsolidationen
dc.typeArtículos de Publicaciones Periódicases
dc.typeinfo:eu-repo/semantics/acceptedVersion
dspace.entity.typeArtículo de Publicación Periódica
itba.description.filiationFil: Rabinovich Orlandi, Iván. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiationFil: Rabinovich Orlandi, Iván. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
itba.description.filiationFil: Fullio, Camila L. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiationFil: Fullio, Camila L. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
itba.description.filiationFil: Schroeder, Matías Nicolás. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiationFil: Giurfa, Martin. Université de Toulouse
itba.description.filiationFil: Giurfa, Martin. Fujian Agriculture and Forestry University; China
itba.description.filiationFil: Ballarini, Fabricio. Universidad de Buenos Aires. Facultad de Medicina; Argentina
itba.description.filiationFil: Ballarini, Fabricio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
itba.description.filiationFil: Ballarini, Fabricio. Instituto Tecnológico de Buenos Aires; Argentina

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