Behavioral tagging underlies memory reconsolidation

Miniatura
Fecha
2020-07
Autores
Rabinovich Orlandi, Iván
Fullio, Camila L.
Schroeder, Matías Nicolás
Giurfa, Martin
Ballarini, Fabricio
Moncada, Diego
Título de la revista
ISSN de la revista
Título del volumen
Editor
Resumen
"Memory reconsolidation occurs when a retrieving event destabilizes transiently a consolidated memory, triggering thereby a new process of restabilization that ensures memory persistence. Although this phenomenon has received wide attention, the effect of new information cooccurring with the reconsolidation process has been less explored. Here we demonstrate that a memory retrieving event sets a neural tag, which enables the reconsolidation of memory after binding proteins provided by the original or a different contiguous experience. We characterized the specific temporal window during which this association is effective and identified the protein kinase A (PKA) and the extracellular signalregulated kinase 1 and 2 (ERK 1/2) pathways as the mechanisms related to the setting of the reconsolidation tag and the synthesis of proteins. Our results show, therefore, that memory reconsolidation is mediated by a “behavioral tagging” process, which is common to different memory forms. They represent a significant advance in understanding the fate of memories reconsolidated while being adjacent to other events, and provide a tool for designing noninvasive strategies to attenuate (pathological/traumatic) or improve (education-related) memories. "
Descripción
Citación
Colecciones