Lipid electropore stabilization

Fernández, María Laura; Risk, Marcelo

Capítulo de libro:
Lipid electropore stabilization

dc.contributor.author	Fernández, María Laura
dc.contributor.author	Risk, Marcelo
dc.date.accessioned	2019-08-28T18:15:36Z
dc.date.available	2019-08-28T18:15:36Z
dc.date.issued	2017-08
dc.description.abstract	"The stabilization of pores can be studied by different approaches such as simulations in silico or experimental procedures in vivo or in vitro. The energy to open a pore in a lipid membrane can be delivered by different external stimuli. To disrupt the membrane and initiate the pore opening, this energy has to reach a threshold. Then, once the pore is open, the external stimulus can be modulated to maintain the pore stable in time. This chapter first describes the basics of electropermeabilization, a process also called electroporation, and the basics of molecular dynamics in electropermeabilization. The chapter then describes in detail the molecular changes that lead to the pore opening and evolution by molecular dynamics. The chapter focuses on molecular dynamics because this technique allows the study of pore stabilization at molecular level, the interpretation of the lipid and water molecule rearrangements that are behind this phenomenon, and the visualization of the pore at the scale of size and time, in the order of nanometers and nanoseconds, respectively. Finally, the chapter also describes other approaches where pores remain open or the permeabilized state remains stable for a period of time, such as continuum modeling, experiments in planar membranes, and experiments in cells. The objective of this selection is to relate the results obtained by molecular dynamics with those obtained experimentally, or by other types of modeling, aiming to connect the mechanisms of pore stabilization by molecular dynamics at different scales."	en
dc.identifier.isbn	978-3319-32-885-0
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/1741
dc.language.iso	en	en
dc.relation	info:eu-repo/semantics/altIdentifier/doi/10.1007/978-3-319-32886-7_83
dc.relation	info:eu-repo/grantAgreement/CONICET/PIP GI/11220110100379/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/UBA/UBACyT/GC/20620130100027BA/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/ITBA/ITBACyT/2015/AR. Ciudad Autónoma de Buenos Aires
dc.subject	DINAMICA MOLECULAR	es
dc.subject	ELECTROPORACION	es
dc.subject	LIPIDOS	es
dc.title	Lipid electropore stabilization	en
dc.type	Capítulos de libro	es
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Capítulo de libro
itba.description.filiation	Fil: Fernández, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Fernández, María Laura; Universidad de Buenos Aires. Argentina.
itba.description.filiation	Fil: Risk, Marccelo. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Risk, Marccelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.