Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling

Busatto, Carlos; Berkenwald, Emilio; Nicolás, Mariano; Casis, Natalia; Luna, Julio; Estenoz, Diana

Artículo de Publicación Periódica:
Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling

dc.contributor.author	Busatto, Carlos
dc.contributor.author	Berkenwald, Emilio
dc.contributor.author	Nicolás, Mariano
dc.contributor.author	Casis, Natalia
dc.contributor.author	Luna, Julio
dc.contributor.author	Estenoz, Diana
dc.date	info:eu-repo/date/embargoEnd/2018-03-01
dc.date.accessioned	2022-04-18T20:25:54Z
dc.date.available	2022-04-18T20:25:54Z
dc.date.issued	2015-12
dc.description.abstract	"The homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) (PLGA) microspheres was investigated. A mathematical model was developed that estimates the evolutions of ester bonds concentrations and average molecular weights along the degradation process. The model is based on a detailed kinetic mechanism that includes the hydrolysis of the different types of ester bonds by random chain scission and considers the effect of polymer chemical composition and molecular structure. Novel and published experimental data were used to adjust and validate the model. The experimental work consisted of homogeneous hydrolytic degradation of PLGA microspheres. The predictions are in very good agreement with the experimental results."	en
dc.identifier.issn	0141-3910
dc.identifier.uri	http://ri.itba.edu.ar/handle/123456789/3792
dc.language.iso	en	en
dc.relation	info:eu-repo/semantics/altIdentifier/doi/ 10.1016/j.polymdegradstab.2015.12.018
dc.relation	info:eu-repo/grantAgreement/CONICET/PIP/848/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/ANPCyT/PICT/2011-1254/AR. Ciudad Autónoma de Buenos Aires
dc.relation	info:eu-repo/grantAgreement/UNL/UNLCyT/2011-419/AR. Santa Fe. Santa Fe
dc.subject	ESTERES	es
dc.title	Homogeneous hydrolytic degradation of poly(lactic-co-glycolic acid) microspheres: Mathematical modeling	en
dc.type	Artículos de Publicaciones Periódicas	es
dc.type	info:eu-repo/semantics/acceptedVersion
dspace.entity.type	Artículo de Publicación Periódica
itba.description.filiation	Fil: Busatto, Carlos. Universidad Nacional del Litoral; Argentina.
itba.description.filiation	Fil: Busatto, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Berkenwald, Emilio. Instituto Tecnológico de Buenos Aires; Argentina.
itba.description.filiation	Fil: Nicolás, Mariano. Universidad Nacional del Litoral; Argentina.
itba.description.filiation	Fil: Nicolás, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Casis, Natalia. Universidad Nacional del Litoral; Argentina.
itba.description.filiation	Fil: Casis, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.
itba.description.filiation	Fil: Luna, Julio. Universidad Nacional del Litoral; Argentina.
itba.description.filiation	Fil: Luna, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina.